Archive for category: Disease

Information and news about disease category

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Cholera in the Developing World

In the 1800s, cholera emerged from its place of origin in India and ravaged the world. Millions have died in the seven cholera pandemics that have occurred since the first appearance of the disease. While it has been eradicated in some regions, others continue to suffer from recurring epidemics.

Cholera is rarely seen in industrialized countries due to proper sanitation systems. Additionally, the World Health Organization (WHO) states that up to 80 percent of cholera cases can be “successfully treated with oral rehydration salts.” However, the bacteria that causes cholera can easily “continue to thrive” in areas with poor sanitation and overcrowded housing. While the developed world may not face the threat of cholera, in recent years, developing nations have seen deadly outbreaks.

Cholera is an “acute diarrheal disease,” which, in severe cases, can cause “profuse watery diarrhea,” vomiting, and muscle cramps. The Centers for Disease Control and Prevention reports that even more severe symptoms include “acute renal failure, severe electrolyte imbalances and coma.” The disease is potentially fatal just hours after developing symptoms.

The severity of cases often varies, says the WHO. Of those infected with the bacteria, 75 percent do not develop symptoms. While this may seem like a non-issue, the bacteria continue to exist in their fecal matter for up to two weeks. Without proper sewage sanitation, others may come in contact with the bacteria as well.

The remaining 25 percent of people infected do develop symptoms. However, 80 percent of those with symptoms only have mild or moderate ones. The other 20 percent of people experience serious, potentially deadly symptoms.

In 2008, the Vietnamese city of Hanoi experienced a cholera outbreak that produced upwards of 2,490 cases. The outbreak was attributed to sewage from septic tanks contaminating lakes where people sometimes wash food. Additionally, street food stalls and “dog meat” restaurants were closed down due to improper sanitation. Thirty lakes in Hanoi had to be sanitized due to the presence of cholera bacteria.

A cholera outbreak in Haiti, which began in 2010, has claimed 8,562 lives, according to the New York Times. Although relief efforts have reduced the number of cases, “clean drinking water and sanitation remain as scarce as when the epidemic began.” The number of cholera treatment centers has shrunk from 120 to 40, and the number of patients dying in treatment centers is rising. Doctors fear that the rainy season will cause the number of cases to skyrocket.

Medical News Today reports the ominous prediction that a cholera outbreak will strike Iraq. “Cholera is endemic in northern Iraq” already, says the report, and with the number of displaced people and refugees rising, the risk is even higher. Syrian refugee camps are overflowing with people, putting the water and sanitation standards at stake.

Two oral cholera vaccines exist, though the WHO has never recommended the vaccine “due to its low protective efficacy and the high occurrence of severe adverse reactions.” The best way to handle an outbreak, says the WHO, is to provide “prompt access to treatment, and to control the spread of the disease by providing safe water, proper sanitation and health education.”

These solutions, however, need to be applied in areas with the greatest need. The United Nations has come under fire for its response to the cholera outbreak in Haiti. The UN has failed to raise the amount of money necessary for vaccinations. While that would provide some immediate relief, Haiti also lacks the $2 billion necessary to construct safe water and sanitation services. Lasting relief is still in the distant future for the slowly recovering nation.

– Bridget Tobin

Sources: WHO 1, WHO 2, Medical News Today, IRIN, CDC, The New York Times
Photo: Medical News Today

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All About Dengue Fever

Dengue Fever
Though similar to malaria in its mode of transmission, dengue fever is its own monster. With up to 400 million people infected every year, dengue has been a leading cause of illness and death worldwide since the 1950s. According to the World Health Organization (WHO), 2.5 billion people around the world are at risk of contracting dengue fever.

Dengue is spread through the bite of a female Aedes aegypti mosquito, a species that seeks out prey during the daytime. The mosquito has recently spread to areas in North America and Europe, though it typically resides in tropical areas. Its presence in tourist destinations like Puerto Rico have caused a global spread, and put more people at risk.

Upon contracting dengue, symptoms present in a manner similar to the flu with high fever, headache, aches and pains and vomiting. The secondary symptoms require immediate treatment to ensure that dengue runs its course without escalation.

However, in developing countries where adequate medical care is unavailable, dengue fever escalates to dengue hemorrhagic fever, which is characterized by more extreme symptoms including hemorrhaging. This can then lead to dengue shock syndrome, and in 50 percent of shock cases there is a fatality.

There is no vaccine or treatment for dengue fever, but there are many preventative measures that can be taken to minimize infection. Insecticide can prevent transmission of the virus, as can mosquito nets and clothing that covers exposed skin. Additionally, proper disposal of waste and trash can cut down on mosquitoes.

While in developed countries dengue fever is very survivable, usually lasting between two and seven days, this virus hits the developing world much harder. Not only is there a higher prevalence in many impoverished tropical areas, they are also least equipped to prevent and handle dengue fever when it occurs.

The presence of such a debilitating and sometimes fatal disease worsens the poverty conditions in a country, in which a community needs resources and money to better protect themselves from the disease. Before that can happen, they need to be able to establish a healthy community to begin the transition out of poverty. This vicious cycle is difficult to overcome, making organizations like the World Health Organization instrumental in keeping these countries afloat.

The WHO assists in minimizing the burden of dengue fever by supporting “countries in the confirmation of outbreaks through its collaborating network of laboratories,” providing “technical support and guidance to countries for the effective management of dengue outbreaks,” and a slew of other helpful measures.

Raising awareness about the causes of dengue fever, as well as how to prevent it in the first place, is the first and most important step toward minimizing outbreaks, especially in the developing world. With the assistance of humanitarian organizations and the training of medical professionals to better respond to the virus, dengue fever will become a more manageable virus with fewer fatalities.

— Maggie Wagner

Sources: CDC, WHO, MedicineNet.com, National Institute of Allergy and Infectious Disease
Photo: NY Times

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Biosecurity and Global Health

The spread of infectious diseases is not only a threat to global health, but also to global security.

In recent years, diseases such as mad cow disease, avian flu, antibiotic-resistance tuberculosis and  antibiotic-resistant malaria have spread around the world. In a global age, the spread of disease becomes very easy. Eradicating infectious diseases and establishing effective ways to combat their spread is becoming important to national security.

In February of this year, the President Obama began the Global Health Security Agenda. Led by the United States, this agenda is a collaboration of 30 countries that is seeking to establish a world that is not threatened by the spread of infectious diseases.

In order to reach the goal, the Agenda  seeks to implement better systems of prevention, detection and response for infectious diseases around the world.

As part of prevention, the Agenda is creating laboratories around the world that are able to identify antimicrobial-resistant organisms, enhance biosecurity and biosafety, encourage the elimination of diseases spreading from animals to humans and improve access to vaccinations.

The Agenda is improving detection through improved biosurveilance and diagnostic tests and is also funding the placement of epidemiologists around the world.

In addition, the Agenda is working to set in place a coordinated response to any threats of infectious disease outbreaks.
Most of the efforts that organizations, such as the World Health Organization, are involved with laboratory practices. By providing safe and secure laboratories, much of the spread of infectious diseases is reduced. In addition, through increased training and education, many of the threats can be reduced.

Although biosecurity is often not a focus of national security, diseases can eradicate the human population as effectively as man-made weapons. By working to improve the resources available as well as improve worldwide practices of prevention, detection and response, much of the biosecurity risk can be eliminated.

– Lily Tyson

Sources: World Health Organization 1, World Health Organization 2
Photo: Science Media Centre

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3 Most Infectious Diseases Among Children

infectious diseases among children
Every year, more than six million children die before they reach their fifth birthday due to preventable infectious diseases according to the U.N. In a recent report, USAID revealed that the following three diseases are the greatest contributors to that statistic:

3 Most Infectious Diseases Among Children

  1. Pneumonia is the cause of approximately 17 percent of deaths in children under the age of five. Especially among infants, pneumonia is a serious lung infection. Pneumonia causes more deaths in children than AIDS, malaria, and measles combined according to UNICEF.
  2. Diarrhea is the second most deadly condition for children under five, causing nine percent of deaths. Compared to adults, children are particularly susceptible to diarrhea because a greater proportion of their body weight is made up of water. Even though it is such a dangerous condition for children, only 44 percent of children in developing countries suffering from diarrhea receive treatment according to the World Health Organization (WHO).
  3. Malaria closely follows diarrhea, causing about seven percent of all child deaths. Even though malaria is easily spread through a mosquito bite, this disease can be just as easily prevented through insecticide-treated mosquito nets and effective antibiotics. Although 1.1 million deaths caused by malaria have been averted since the start of the U.N.’s Millennium Development Goals in 2000, malaria is still a major health issue in developing countries.

Pneumonia, diarrhea and malaria together account for about a third of all child deaths globally. The symptoms and effects of these diseases can become severe if the infected person is malnourished or does not receive the proper necessary treatment. As a result, these three diseases are all the more rampant in developing countries.

Similarly to the U.N.’s goal to reduce the child mortality rate by two-thirds, WHO and UNICEF staff members worked together to create the Global Action Plan for Pneumonia and Diarrhea (GAPPD). This integrated plan seeks to end child deaths caused by these two preventable diseases by 2025. The GAPPD will also combine the practices for treating both pneumonia and diarrhea since the causes and treatment for these two diseases are interrelated.

Global poverty is directly related to the spread of infectious diseases in developing countries. This is why The Borgen Project along with so many other organizations work to decrease the multi-layered issue of poverty across the globe.

– Meghan Orner

Sources: Daily Times, WebMD, World Health Organization, World Health Organization
Photo: UNICEF

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Arsenic Poisoning in Rural Asian Waters

Arsenic
Reawakening the global health problem of unclean, polluted drinking water, rural Asian villages have been plagued with arsenic-ridden water. Most of these rural villages are near mines which leak and pollute local water sources with the carcinogen arsenic. In the past decade, the Heshan village in China has seen nearly 20 percent of the population get cancer from the polluted water.

The arsenic has been traced back to runoff and residue from a local mine that was closed in 2011. The 190 living cancer patients have petitioned the local governments for monetary compensation and aid, but the $1,600 reimbursement is insufficient for even one round of chemotherapy or radiation. For many of these poor rural villagers, the cancer diagnosis from arsenic poisoning is nothing less than a death sentence because of the unaffordable cost of treatment.

Tests of the ground water have resulted in arsenic amounts 15 times the safe amount of arsenic. The water is so toxic that many of the agricultural staples are not viable in the region, stripping these people of their livelihood and reinforcing the cycle of poverty in the area.

Similar cases have been reported throughout China and India. With water security being of the utmost importance, cancer patterns have sprung up around villages with arsenic in the water. Local medical professionals have denied the correlation between the high arsenic levels and the cancer hotspots, despite the fact that arsenic has been recognized by many health institutions as a known carcinogen.

The lack of transparency between health officials and the villagers coupled with insufficient cleaning methods has resorted in the outbreaks of cancer caused by arsenic. The toxicity of the element, both for humans and agriculture, has stunted the regional economies and has restricted the employment pool. A needless tragedy, the arsenic-laden drinking waters have destroyed families and the economies of the rural villages afflicted by the toxic water.

– Kristin Ronzi

Sources: American Cancer Society, Reuters, Times of India
Photo: Trip Advisor

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The World’s First Hookworm Vaccine

One-third of children and women living below the World Bank’s poverty line are infected with hookworm today, which often causes moderate to severe anemia. Hookworm and other Neglected Tropical Diseases, or NTDs, disproportionately affect the poorer Islamic countries such as Indonesia, Bangladesh, Mali, Nigeria and others in North Africa and the Middle East.

Children and pregnant women are by far the most drastically affected by this disease. Children with long-standing blood loss from hookworm often experience sufficient mental and motor development delays. They can actually lose IQ points as well. These detrimental effects undoubtedly follow them into adulthood, making productivity more difficult.

The blood loss caused by hookworm may affect women in labor, making their chance of death much higher. Additionally, the baby is more likely to be born prematurely or with low birth weight. This makes those babies less likely to survive, contributing to the child mortality rate.

Additionally, the link between hookworms and anemia is a large concern because of its relation to disabilities. Anemia accounted for 8.8 percent of the total disability of the world in 2010. Today, children under 5 years old and women of all ages still hold the heaviest burden.

Fortunately, the Sabin Vaccine Institute’s Product Development Partnership is developing the world’s first hookworm vaccine for human use. The Sabin Institute was established in 2000 with funding from the Bill & Melinda Gates Foundation and is the only Product Development Partnership in the world working to develop a vaccine for human hookworm infections.

The institute is receiving support from the European Commission FP7 program and uniting professionals from around the world to build research. This global consortium has been coined HOOKVAC and includes members from the Netherlands, the United States, Belgium, England, Germany and Gabon. This project aims not only to perfect the manufacturing process of the vaccine, but also to increase and share research on NTDs.

The first clinical testing of the vaccine will take place in Sub-Saharan Africa once it is ready. Gabon’s Lamberene Research Centre will lead clinical testing in adults and children in Gabon, a region plagued with hookworm.

The vaccine is being called the “anti-poverty” vaccine due to its vast potential to lower child mortality rates, save mothers in labor and improve health conditions for agricultural workers, who are the backbone of many poorer economies.

The vaccine, as of now, is intended only for use in the poorest regions of the world, where hookworm thrives. This means that the product will likely not be sold commercially by pharmaceutical companies, but will remain in the nonprofit sector with HOOKVAC.

The project will hopefully conduct trials in the coming years and bring health relief to millions, while contributing to the united fight against global poverty.

– Cambria Arvizo

Sources: Huffington Post, Sabin Vaccine Institute, American Society of Hematology
Photo: The Guardian

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Chickungunya Virus Spreading Fast

Chickungunya

North Carolina’s first case of the Chickungunya virus was confirmed on June 12. Seven days later Georgia confirmed its first case. Two days after that Tennessee confirmed its second. With over 30 cases already confirmed in Florida, this mosquito-borne virus is quickly spreading.

Until 2007, Chickungunya was only found in Africa, Asia and the Indian subcontinent. Then it appeared in Italy and slowly made its way throughout Europe. In December of this past year the first case of Chickungunya was reported in the Caribbean. Now, barely six months later, the Pan American Health Organization has confirmed 5,000 cases of the virus and suspects another 160,000 cases in the region.

There is currently no vaccine for the virus or treatment for the symptoms. Those symptoms include fever, rash, nausea, chronic joint pain, swelling and headache. They usually first appear within three to seven days after infection with most symptoms abating after about a week’s time. However, the joint pain often lasts for months.

There are now 20 afflicted states and islands in the Caribbean, with Cuba being the most recent. The Center for Disease Control has reported approximately 60 total cases in the continental United States thus far. All such cases have included patients who have made recent trips to the Caribbean. The virus has been linked to the Aedes aegypti and Aedes albopictus mosquitoes, both of which are fairly common in the U.S. The CDC has recommended that people who are traveling to the Caribbean use bug spray and dress in long sleeves and pants to avoid being bitten by either kind.

Despite rising concerns about possible contraction of the Chickungunya virus, trips to the Caribbean remain popular among American tourists. With cruise season currently in full swing, the number of cases in the U.S. is sure to rise.

— Taylor Dow

Sources: LA Times, Island Gazette, CNN, AJC, Medpage Today
Photo: Wageningen Ur

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END7 Diseases by 2020

END7
END7, an international advocacy campaign, aims to end seven neglected tropical diseases (NTDS) by 2020. It is currently raising awareness of the seven most common NTDs, and the easy and cheap resources available to eliminate them.

Cheap is not an understatement — it takes only 50 cents to treat and protect one person against all seven NTDS.

While 2020 may seem like an overly optimistic date to have eliminated seven diseases, treatments for all NTDs exist — it’s just a matter of getting them to those in need. The seven diseases include Hookworm, Roundworm, Whipworm, Elephantiasis, Trachoma, River Blindness and Snail Fever.

Nearly one in six people worldwide, including over half a billion children, have these diseases living and breeding inside their bodies. The effects of these diseases can be devastating, causing blindness, massive swelling in limbs, severe malnutrition, pregnancy complications and anemia.

Apart from the horrific effects of NTDs, these diseases makes it increasingly difficult for affected families to lift themselves out of poverty. They prevent children from going to school.

In order to spread the word about their cause and the work being done to help victims of NTDs, END7 utilizes social media outlets, hoping to target young activists who will then share the word with others. The goal is to get the general public involved, not just doctors and health care professionals.

The campaign asks the community to donate to NTD prevention and treatment programs. These programs deliver the medications to schools and poor communities all over the globe.

How can it be so cheap? Drugs to treat NTDS are donated by pharmaceutical companies, allowing for the remaining cost to come only in distributing the drugs to those in need.

Bill Nighy, who provides a voice for many of the END7 videos, describes his astonishment in the opportunity at hand, stating, “I’m shocked by how much devastation these diseases cause. But what shocks me more is how simple the solution is.”

If pocket change can provide a cure for seven diseases, it seems that a cure in 2020 may not seem so far out of reach after all.

 — Caroline Logan

Sources: END7, TwitChange
Photo: Northeastern

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10 Facts About Malaria

It is well known that mosquitoes carry diseases. Even in developed nations like the U.S., there are yearly warnings of West Nile Virus and Eastern Equine Encephalitis, but no disease carried by mosquitoes is as widespread as malaria. The following 10 facts about malaria shed some light on the global malaria epidemic, what is being done about it and what the future holds.

 

Top 10 Facts About Malaria

 

1. The word “malaria” means “bad air.” In the 18th century people thought that malaria was caused from breathing in bad air in marshy areas. In 1880 scientists discovered that this was not true, but the name stuck.

2. Malaria is spread by parasites. Five different parasites can cause malaria in humans, but the Plasmodium falciparum parasite is the most deadly. The parasites enter the human bloodstream through the bite of an infected mosquito.

3. Malaria is most commonly found in Africa and parts of Southeast Asia. Mosquitoes thrive in tropical and subtropical climates, so countries that are near the equator are more at risk. Additionally, many African and Southeast Asian countries have high poverty rates and people do not have access to malaria prevention and treatment, or are not educated on the disease.

4. Malaria can pass from human to human. You cannot “catch” malaria like you can a cold, but people can pass it on by sharing needles, blood transfusions and through pregnancy.

5. When infected with malaria, symptoms can range from none to severe. It can take anywhere from 9-40 days for symptoms to appear. Early symptoms can include fever, nausea, vomiting, fatigue, chills, headache, muscle aches, cough and sweating. If not treated within 24 hours the disease can worsen, leading to seizures, impairment of brain and spinal cord function, loss of consciousness and death.

6. Malaria infects an average of 200 million people each year. Up to 1 million of these 200 million will die every year. Of malaria deaths, 90 percent occur in Africa. In Africa one child dies from malaria every minute.

7. There is a cure for malaria. There are different drug treatments available depending on the strain of malaria an individual is infected with. The drugs cure malaria by killing all of the parasites within a person’s bloodstream. However, new waves of drug-resistant malaria are threatening the lives of millions.

8. The best cure for malaria is prevention. There are two major ways that malaria is prevented. Insecticide-treated mosquito netting placed around beds is a good way to keep people safe while they sleep, and spraying a household with residual insecticide will effectively eliminate mosquitos in the house for three to six months.

9. Mortality rates are falling. Since 2000, malaria mortality rates have fallen by 42 percent globally. This is largely due to increased prevention and faster testing and treatment to those who are thought to have malaria. By 2015, 52 countries are expected to have reduced their number of malaria cases by 75 percent. In the past four years the countries of Morocco, United Arab Emirates, Turkmenistan and Armenia have been certified by the World Health Organization as having eliminated malaria.

10. There is a promising vaccine currently being tested. While there is currently no vaccine on the market to prevent against malaria, there is one being tested via clinical trial in seven African countries with positive results. Scientists feel very encouraged by this new treatment and the vaccine could be ready for full-time use as early as 2015.

These 10 facts on malaria depict the fact that although malaria is a curable and preventable illness, millions of people still contract it every year. Those who contract it mainly reside in poor countries where access to quality health care and education is more difficult to come by. If these people receive the proper education on malaria, as well as access to medications, then there would be no reason for anyone to be dying from this disease.

— Taylor Lovett

Sources: CDC, Medical News Today, WHO
Photo: Flickr

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Breakthrough Discovered in the Treatment of TB in Children

New findings in tuberculosis among children could mean that diagnosing the disease could be faster, cheaper and more effective for the millions of people infected by the disease each year.

Tuberculosis (TB) is the second largest killer due to a single infectious agent worldwide, only following HIV/AIDS, and is the leading killer of people with HIV. The ones most affected by the disease are low to middle-income countries, where upwards of 95 percent of TB deaths occur.

Developing countries where malnutrition and compromised immune systems affect the overwhelming majority see the most cases of TB. Even though all groups are at risk, children and young adults are at a greater risk of contracting the disease.

The disease is very difficult to diagnose in children — the early symptoms of TB are also present in dozens of other illnesses — and by the time a positive diagnosis is reached, the disease has already spread throughout the lungs, brain and other organs.

In 2012 alone, there were 530,000 cases of TB in children, and out of the children who were HIV-negative, 74,000 died of the disease because of late and improper diagnosis.

A better diagnosis is needed so that doctors can start treating TB earlier (in its early stages) for better chances of overcoming the disease and so children who show false positives for TB do not need to go through unnecessary treatment.

Health staff in several poor countries have been using a standard test for TB which has failed 93 percent of the time, showing false negatives, leaving thousands of infected children untreated.

Recently, after seven years of study and examining the blood of 2,800 children, an international team of researchers discovered that TB can be positively identified by examining 51 genes.

Over 80 percent of cases were discovered positive for TB by examining this specific gene signature. Researchers examined the blood samples to see which genes were activated or suppressed in samples testing positive.

It was found that TB could be distinguished from other diseases in 51 of the 30,000 genes that make up the human genome. A “risk score” was developed from the examination of this gene signature, and when tested, over 80 percent of the samples were accurately diagnosed positive for TB. Tests that were found negative ruled out TB as a diagnosis with just as much accuracy.

“Childhood TB is a major problem in African hospitals. An accurate test for childhood TB would be an enormous breakthrough, enabling earlier diagnosis, reducing long hospital admissions for investigation of TB suspects, and limiting the number of children treated inappropriately,” said head researcher Brian Eley. Eley is part of the University of Cape Town and lead the clinical study in South Africa.

Early, accurate diagnosis of TB would lead to reducing deaths related to TB in children. The discovery of what these 51 key genes demonstrate in relation to TB will help lead the way to a significant global decrease in the disease that currently affects millions.

 — Jerilynn Haddow

Sources: WHO, IRIN Africa, Wellcome
Photo: Blogspot