Archive for category: Disease

Information and news about disease category

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Global Vaccination Programs

When it comes to diseases, it is always preferred to prevent rather than treat. Over the years, vaccinations and immunizations have saved millions of lives and eliminated one of the deadliest diseases in the world: smallpox.

All children are born with an immune system that produces antibodies when a foreign substance, or antigen, is detected. In other words, when the child gets sick, these proteins will not be able to halt the disease from occurring, but the immune system will remember the antigen and give the child immunity when it invades the body a second time.

Vaccines contain those antigens, but in a weaker form. The body will sense an “invader” and still produce antibodies to fight the harmless antigen. Thus, without ever exposing a child to a disease, a vaccination is a safer way to gain protection and produce immunity.

The Centers for Disease Control and Prevention understands the importance of global vaccination programs and has created the Global Immunization Division, which is dedicated to creating a “world without the diseases and deaths that could be prevented with vaccines.”

Worldwide, one in five children do not have access to the most basic vaccines. Consequently, around 1.5 million children die each year from diseases that could be prevented with proper immunizations. By working with a variety of global partners, the CDC has implemented a multitude of routine immunization services and campaigns, in addition to providing bed nets, de-worming medication and safe water systems.

The Bill and Melinda Gates Foundation also invests in global vaccination programs and contributes to the goals of the Decade of Vaccines, an action plan that aims to deliver universal access to immunization. In collaboration with the World Health Organization and other civil society organizations, the foundation is introducing vaccinations into the countries that need it most. They focus on strengthening immunizations systems by supporting the collection and analysis of vaccine-related data, as well as developing new technology to help medical staff “assess population immunity to disease.”

Universal access to vaccinations remains a priority goal for both groups in the next year. Effective vaccination programs saves lives, is inexpensive and easy to administer. Universal availability of vaccines also reduces health inequities, if everyone can have access to life-saving discoveries. Access to vaccines will give all our global citizens a fighting chance to survive.

– Leeda Jewayni

Sources: CDC, CDC 2, Bill and Melinda Gates Foundation
Photo: Council on Foreign Relations

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The Pentavalent Vaccine

Pentavalent is a vaccine that is being used to protect against five diseases: tetanus, hepatitis B, Pertussis, haemophilus influenza type b and diptheria. The Global Alliance for Vaccines and Immunizations (GAVI) introduced the vaccine in 2001 in Kenya, and in July of 2014 South Sudan became the 73rd country to be introduced to the vaccine through the GAVI Alliance.

In order for the vaccine to be effective, it needs to be administered over a three-dose schedule. Increasing the availability of the pentavalent vaccine is an attempt to reduce the mortality rate of children under the age of five by two-thirds for the coming year (2015), which is goal number four on the Millennium Development Goals list.

GAVI has also partnered with organizations such as World Bank, WHO and UNICEF, as well as other donor countries, in order to increase the availability of the pentavalent vaccine in poor countries where child mortality is an extremely pressing concern.

Most recently, the Minister of Health in India, Harsh Vardhan, stated that the pentavalent vaccine would be introduced in eight of India’s states: Tamil Nadu, Gujarat, Karnataka, Puducherry, Kerala, Goa, Jammu and Kashmir and Haryana. The plan is for the vaccine to be distributed among twelve additional states in the near future.

The success rate of disease prevention once the pentavalent vaccine has been administered is extremely high; the next part of the plan regarding the vaccine is to make sure that coverage is provided in remote areas and in regions facing deep levels of poverty. GAVI plans to begin an initiative, to be implemented from 2016 to 2020, to increase the amount of coverage for the pentavalent vaccine worldwide.

The CEO of the GAVI Alliance, Dr. Seth Berkley, stated on the GAVI website that his “next challenge is to support some of the world’s largest countries to expand and strengthen their programmes to ensure they are reaching every child.”

– Jordyn Horowitz

Sources: GAVI Alliance, UNICEF, Business Standard
Photo: GAVI Alliance

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What is the MMR Vaccine?

mmr vaccine
Measles, mumps and rubella are all viral diseases that can interrupt the development of children and adolescents. Accessing reliable information about the MMR vaccine is the most cost-effective method to increasing its uptake.

The MMR vaccine is recommended in childhood. The three-in-one vaccine is necessary for most children to enter school and can be given as early as 11-15 months, and children should get two doses. In addition, adults born after 1956 or 18 years or older should also receive one dose of the vaccination unless they have already had all three diseases.

The MMR vaccine can be given at the same time as other vaccines. Young children (under 12 years) can get a combination of vaccines known as the MMRV (measles, mumps, rubella and chicken pox).

Upon receiving the vaccination, there are some risks involved, but most people who receive the vaccine do not develop any problems.

Mild issues can occur 6-14 days after receiving the vaccine and can include any of the following: fevers, mild rashes, and swelling of cheek/neck glands. Moderate issues can range from: seizures, stiffness/ pain in joints, temporary low platelet count that leads to a bleeding disorder (1 in every 30,000 doses). Some severe and very rare problems are: serious allergic reaction (1 in every million doses), deafness, permanent brain damage, and long-term seizures/comas. There is no evidence that the vaccine causes childhood autism.

All of these listed risks are small however, in comparison with the risks of contracting measles: severe illness, hospitalization and death. The vaccine itself has brought huge leaps in early childhood disease prevention, providing vaccination to over 500 million people worldwide in over 100 countries. Before the vaccine, mumps was the most common cause of viral meningitis in children and rubella caused terrible damage to unborn babies.

Now, both mumps and rubella are virtually non-existent in children.

The Measles Outbreak

With concern to the current measles outbreak of 2014, two doses are recommended because 2-5 percent of vaccinated people do not respond to their first dose. More than 99 percent of people develop immunity after
the second dose.

Out of the 593 confirmed cases of measles, very few were from people who had been vaccinated twice.

The virus itself can stay in the air for two hours after a person with measles symptoms have left the area and is spread by respiratory droplets. The people infected are contagious four days before and after receiving the rash.

International Outbreak

In the third world countries of the world, measles outbreaks have been spreading more freely, with thousands of cases. In the Philippines, there were 50,000 registered cases and 77 deaths. In Vietnam, there are at least
8,700 cases with 112 deaths in children. In Pakistan, over 30,000 people have caught measles and 290 people have died, with the number increasing daily for children alone. The effect of measles has been spreading due to a lack of proper vaccination, more vulnerable immune systems and misinformation (MMR vaccine may produce autism).

In Africa, the number of measles-related deaths have decreased by 91 percent due to a surge in immunization. However, cases have still been growing, a number well into the thousands.

The potential benefits of the vaccine outweigh the risks. Parents should understand that the MMR vaccine is the best way to protect their children from these diseases, especially if traveling to an affected area, or the family resides in an affected area.

– Ashley Riley

Sources: About, About 2, CDC, CDC 2
Photo: Medimoon

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Climate Change and Pathogen Ranges

The effects of climate change are numerous: ocean levels are rising, meteorological events are becoming stronger and increasingly unpredictable and the incidence of heat-related illness is increasing across the world. Yet experts are just beginning to understand one effect of a changing climate: the capacity for pathogens to migrate around the globe and infect populations that have previously never been in contact with these microorganisms.

Combined, these effects have the potential to cause extreme poverty. Loss of property and life resulting from rising sea levels and strong storms deprive people of both wealth and other resources.

However, the global health conundrum that is changing pathogen ranges is also a poverty issue in its own right. Poor human health places burdens on individuals and their family members that may cause them to lose employment opportunities and large sums of money. Being ill is no easy fortune, but the impoverishment that often accompanies illness can be worse yet.

As warming weather drives animals toward more hospitable environments, pathogens too are expanding their ranges and at the same time, are finding hosts they’ve never met. While it’s working out well for these pathogens, humans, other animals and plants aren’t faring too well.

A species of sea otters in the Pacific Ocean off the coast of Alaska has become ill from a virus that originated in the northern Atlantic Ocean; science writer Chris Solomon suggests that due to declining sea ice levels, “disease is finding new lanes of travel.”

It makes sense – pathogens are highly dependent on temperature for survival, and many bacteria and viruses thrive in the type of warm, wet environments that are becoming more and more prevalent as the climate changes. Not only do rising sea levels give pathogens access to a wider range of space (and accordingly, hosts) but also as animals move around seeking cooler climates, they take pathogens and parasites along with them, allowing them to infect entirely new populations.

What does this mean for humans? Well, the effects of expanding pathogen ranges are manifold. First, like Alaska’s sea otters, humans may soon fall prey to microorganisms not previously seen in their parts of the world. Prevention and treatment of illnesses caused by unfamiliar pathogens will be difficult and costly.

Inevitably, some humans – though it is impossible now to estimate just how many – will die.

Since human health is directly related to poverty outcomes, the expanding pathogen ranges means expanded poverty “ranges;” if more people fall ill due to pathogens, more people will experience poverty.

Secondly, and this is an effect that agricultural communities are already beginning to observe, new pathogens will infect crops and jeopardize the livelihood of the peoples who depend on the harvest for either food or for employment.

According to a study from the Universities of Exeter and Oxford, crop threats include pests and pathogens spreading toward the poles at a rate of 3.2 kilometers per year. A fungus that infects yeast harvests has already wreaked havoc in Brazil, threatening farmers there with impoverishment.

It’s difficult to fathom that such tiny organisms could have such large effects, but pathogens have the potential to cause a lot of harm, in terms of both illness and poverty. Despite that their migration is one of the least publicized effects of climate change; however,  it is one of which humans should be wary.

– Elise L. Riley

Sources: NPR, NASA
Photo: Phys.org

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Yellow Fever in the Developing World

Despite increased understanding of the mosquito-transmitted disease since it presented in the 15th century, yellow fever in the developing world continues to have a widespread effect. The World Health Organize  estimates that there are 200,000 cases of yellow fever every year, with 30,000 deaths, 90 percent of which occur in Africa. In Africa and Latin America, 900 million people are at risk of infection as the disease spreads without a cure.

When a mosquito bites a person and transmits yellow fever, there are two paths the disease can take. It will either present as flu like symptoms with fever, aching and nausea, before going away in three to four days. However, 15 percent of patients take the second path. Symptoms worsen rapidly, as the patient develops jaundice, bleeding and increased vomiting. Half of these patients die within 14 days, and those who survive suffer from severe organ damage.

The fight against yellow fever is challenging for a few reasons. For starters, in the early stages, it is difficult to diagnose the disease, as its symptoms are similar to diseases like malaria, viral hepatitis and poisoning. Once the disease can be identified, it is often too far along to effectively control.

Additionally, yellow fever has no treatment. Though it can be prevented, there is no vaccine to cure it. Patients are often treated for secondary conditions that result from yellow fever, which can be effective in helping the patient survive the disease.

Despite the lack of treatment, there are myriad methods to prevent yellow fever. The GAVI Alliance, which has brought together the efforts of the WHO, UNICEF, the World Bank, the Bill and Melinda Gates Foundation and various other governmental agencies, has been successful in administering preventative vaccines worldwide. Since GAVI got involved, an estimated 64 million children have had the vaccine, and 17 of the 33 countries at risk have received routine vaccinations.

In addition to vaccination, protection from mosquitoes can be effective in preventing yellow fever, whether it be insecticide treated nets, clothing that covers as much skin as possible or remaining indoors at night when the mosquitoes are in abundance.

The WHO has been involved beyond its participation in the GAVI Alliance, acting as Secretariat for the International Coordinating Group for Yellow Fever Vaccine Provision. The ICG is adamant about maintaining a stockpile of yellow fever vaccinations in case of a sudden outbreak. Additionally, the WHO along with UNICEF and national governments has led the Yellow Fever Initiative which focuses its vaccination efforts in Africa, targets infants younger than nine months and works to monitor outbreaks to minimize damage.

Preventing yellow fever is very much dependent on efficient healthcare and sanitation, things that are difficult to achieve in impoverished areas. The efforts of GAVI, as well as the individual organizations, are crucial to control the number of yellow fever cases every year.

– Maggie Wagner

Sources: Gavi Alliance, NCBI, WHO
Photo: Gavi Alliance

Ebola in Sierra Leone

The Ebola outbreak spreading across Africa has become increasingly fatal over the past couple of months. The incubation period for Ebola ranges from two days to 21 days, and when not treated early on, has about a 90 percent fatality rate.

According to WHO, 630 people total in the West African countries of Sierra Leone (442 people infected, 206 deaths), Guinea (410 people infected, 310 deaths) and Liberia (196 people infected, 116 deaths) lost their lives to Ebola. One of the most recent victims of the disease includes one of the leading doctors in Sierra Leone, Sheik Umar Khan, who contracted the virus while attempting to help treat others afflicted by Ebola.

Psychologist Ane Bjoru, who has begun work in Sierra Leone, however, explains the impact of Ebola beyond purely the physical effects of the virus. In her article in The Guardian, she explains that as a non-medical staff member, a large part of her job is helping hygienists, who have to deal with disposing of the dead bodies, deal with this “new and disturbing experience” and much of her work “involves helping them with counseling and support.”

Ane Bjoru explains that to treat Ebola in Sierra Leone the hygienists are responsible for cleaning the blood and stool produced by the patients, and are confronted with a confusing mix of emotions when dealing with the dead bodies. They are filled with sadness from the loss, fear from the contagious bodies, and especially in Sierra Leone where the dead are usually dealt with by the elders of the society, some of the hygienists feel they are too young to be involved with this part of the life cycle.

Ane Bjoru, through her work, seeks to build a wider community of people to help citizens of Sierra Leone deal with the emotional consequences of the Ebola outbreak.

— Jordyn Horowitz

Sources: World Health Organization, The Guardian 1, The Guardian 2, BBC News
Photo: The Guardian

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Causes of Malaria

Malaria, a disease largely eliminated in the developed world, remains a health issue for developing nations. According to World Health Organization estimates, 207 million cases of the deadly disease emerged in 2012 alone, with about 80 percent coming from countries in Sub-Saharan Africa.

To help communities in these nations fight malaria, NGOs and foreign aid providers must not only provide malaria treatment methods but also find ways to address and protect people from its causes.

So, what are the causes of malaria?

The Mayo Clinic identifies the main path to infection as the transmission of parasites through mosquitoes. Mosquitoes can carry small parasites that cause malaria, and when they bite humans the parasites can enter the bloodstream. Once in the body, the malarial parasites travel to the liver, where they grow and develop. The maturation process lasts from a week to nearly a year, but once the parasites reach adulthood, they enter the bloodstream and infect red blood cells.

At this stage, the common symptoms of malaria, including fever, chills and sweating, develop. At the same time, mosquitoes that suck infected blood will get the malarial parasites, allowing them to spread through bites to other people.

Though malaria primarily spreads through mosquito bites, people can contract it from other sources. Malaria is a blood-borne disease, and receiving blood transfusions from infected individuals can lead to transmission. Sharing dirty hypodermic needles will also cause malaria to spread, and mothers can pass the disease on to their unborn children.

If left untreated within 24 hours of the first symptoms, malaria can cause brain damage, fluid buildup in the lungs and liver failure, all of which can be fatal. The World Health Organization believes that in 2012 malaria killed 627,000 people, the majority of whom were African children under five.

Fortunately, the mortality rates of malaria have fallen 42 percent globally since 2000. Still, the disease is lethal enough that a child in Africa dies every minute from malaria-related symptoms.

With no existing vaccine for the disease, programs to reduce deaths must focus on preventing malaria and safely treating existing cases.

Knowing that mosquitoes are the primary transmitters of malarial parasites, what do governments and other organizations do to prevent bites?

According to the World Health Organization, the two primary methods to keep mosquitoes away from people and their homes are to use insecticide-treated nets and indoor residual spraying of insecticides.

Projects from NGOs and foreign aid agencies to provide these services to communities free of charge will help prevent mosquitoes from spreading malaria.

While using either insecticide-treated nets or indoor residual spraying to stop mosquito bites is effective, the Institute for Health Metrics and Evaluation found that, in areas of medium transmission, using both methods reduced the risk of infection an extra 36 percent compared to one method alone.

Public education programs to teach people and doctors not to reuse medical equipment, not to give transfusions of infected blood and how to recognize symptoms quickly can also supplement insecticide-treated nets and indoor residual spraying to stop malaria at its source.

Malaria is a dangerous disease that takes the lives of many young children daily, but since people know what causes malaria, it can be prevented. Thanks to technology to kill parasite-carrying mosquitoes, deaths from malaria are dropping and the world is becoming a safer place to live.

– Ted Rappleye

Sources: The Mayo Clinic, World Health Organization, Institute for Health Metrics and Evaluation
Photo: TreeHugger

Rats Detecting Tuberculosis  

Rats are commonly thought to carry disease, but what if they diagnosed disease instead? In fact, they do. Contrary to popular belief, rats are highly intelligent creatures that can be trained to sniff out specific odors with incredible accuracy. They have already been used in warzones to sniff out landmines; now, a research center in Tanzania has rats detecting tuberculosis in patients’ saliva.

The giant rats being trained are especially successful at distinguishing an affected person’s saliva because they can smell “in stereo,” meaning that with one sniff they can differentiate two different odors. One out of every 100 rat genes is dedicated to their olfactory abilities – in humans, only one of every 1000 genes has to do with our capacity to smell. Rats’ superior noses allow them to diagnose a TB patient in only seven minutes. Diagnosis by human physicians can take all day.

Working to make TB diagnosis easier and more accurate is especially important for low- and middle-income countries, where 95 percent of all TB-related deaths occur. If caught early, TB can be treated with a course of antibiotics. Because TB is a bacterial disease, its symptoms may not present for long periods of time; the bacteria, which are spread through the air when affected individuals cough or sneeze, can lie dormant in the body before they begin to cause more severe symptoms. Because rats use the smell of the bacteria rather than a patient’s symptoms to diagnose TB, they can diagnose patients much earlier than doctors can.

Though the equipment and expertise necessary to train these rats can be somewhat expensive, this method has the potential to save over a million lives and prevent illness in nearly nine million more every year.  Foreign aid could be useful in providing trained rats to health centers in developing countries or assisting in the training of rats abroad.

Seeing rats as agents of health rather than disease is the first step to eliminating TB altogether. By bringing these intelligent animals into our health centers and our hearts, we can prevent the transmission of one of the world’s deadliest diseases.

– Elise L. Riley

Sources: World Health Organization, BBC
Photo: Flickr

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Controlling Malaria Outbreaks

Combating poverty drives innovation. In order to reduce the suffering from poverty, countries investigate cost effective methods of preventing poverty and reducing the negative effects of poverty, such as disease or malnutrition. Confronting public health concerns, like malaria, in developing countries inspires scientific innovations to end the problem in an efficient yet inexpensive way. In this way, controlling malaria outbreaks improves health care worldwide.

Malaria is preventable and treatable, yet the disease killed over 600,000 people in 2012. The Center for Disease Control reported that malaria outbreaks are the leading cause of death in many developing countries and disproportionately affects young children, pregnant women and travelers.

Malaria is both a symptom and cause of poverty. Impoverished people struggle to take preventative measures against malaria, and if individuals contract malaria, the cost of treatment and the inability to work burden them. Furthermore, countries must create and manage health facilities and treatments. The Center for Disease Control estimated the direct cost at $12 billion per year. This creates a cycle of poverty in which both people and nations are unable to escape.

Some of the solutions, though, destroy too many mosquitoes, which affects the environment. Many predators depend on mosquitoes as their primary food source, so the ecological effect of eliminating all mosquitoes would be significant.

Because of this, researchers are investigating effective preventive measures to target a specific type of mosquito. The Economist reports that Dr. Nikolai Windbichler and Dr. Andrea Crisanti found a method of killing only the mosquitoes of the Anopheles genus, or the ones that carry malaria. By ensuring that the mosquitoes no longer produce female mosquitoes, Dr. Windbichler and Dr. Crisanti ensure that the mosquitoes cannot reproduce or draw blood and spread the malaria parasite.

The researchers designed a protein called endonuclease, which erodes the X chromosome of the mosquitoes. Producing female offspring requires two X chromosomes, and the egg only holds X chromosomes. As a result, if the protein limits the production of X chromosomes in male mosquitoes, it will limit the amount of female mosquitoes produced. A male dominated species of mosquitoes would lower the population as a whole and limit the transmission of malaria.

However, the Economist notes that natural selection will eventually allow the mosquitoes to evolve past the protein, so this solution depends on the elimination of the parasite within the species.

Ecologist Phil Lounibos expresses some skepticism of this type of solution. He believes that eliminating or decreasing the population of one species will not affect the spread of the disease. In a study he led, multiple genus of mosquitoes would cross inseminate and spread the parasite to other types of mosquitoes.

Stalling the disease, though, could allow countries to divert funds from malaria treatment to increasing economic productivity and improving the lives of the country’s impoverished. Developing new methods of malaria control presents exciting possibilities for controlling and combating malaria.

Between 2000 and 2012, malaria interventions saved over 3 million lives, and scientific innovation could drastically increase this number.

– Tara Wilson

Sources: The Economist, Center for Disease Control, WHO, Nature
Photo: The Health Site

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Five of the Most Common Killer Diseases

The Global Post has drawn up a list of the world’s biggest killers by using information from the World Health Organization. Below are a list of some of our most common killer diseases per country.

5. Cirrhosis of the Liver

Caused by excessive drinking, the disease is unique to Mexico as the only place in the world where it is the primary cause of death. Yet the disease is nothing to roll your eyes at: caused by healthy liver tissue being replaced by scar tissue, the scar tissue blocks the flow of blood, nutrients and other important proteins through the liver. Cirrhosis of the liver is the 12th leading cause of death by disease in the world — except for in Mexico, where it’s number one.

4. Tuberculosis

Tuberculosis is often thought of as a disease of the past, but it is still affecting millions of people around the world. In fact, it’s on the rise — the World Health Organization reports around 500,000 new TB cases each year, and it is second only to AIDS as an infectious killer worldwide. A bacterial infection that can spread through the lymph nodes and blood stream to any other part of the body, TB is the leading cause of death in areas such as Pakistan and North and South Africa.

3. HIV/AIDS

Despite the enormous progress made at slowing down the spread of HIV/AIDS, it is still the leading cause of death throughout most of Africa. Just two years ago, around 25 million people — roughly 70 percent of the global total — were living with HIV/AIDS in Sub-Saharan Africa, and an estimated 1.6 million new HIV infections and 1.2-million AIDS related deaths were reported that same year. In areas such as South Africa, Botswana and Swaziland, the percentage of HIV-prevalence is as high as 26.5 percent.

2. Cancer

It would be hard to find someone not somehow directly affected by cancer. As the second-leading cause of death in the world, cancer has certainly taken its toll — especially in areas such as France, the Iberian peninsula, Austria, Switzerland, the Netherlands and Denmark, where cancer (primarily lung and throat) is the leading cause of death. Classified as the rapid growth of cells, there are more than 100 types of cancer that we currently know about.

1. Heart Disease

It’s no surprise that heart disease tops the list as the world’s deadliest killer, but it is a little shocking to see the massive list of countries where heart disease outranks all other diseases. These countries include Canada, the United States, Russia, Australia, most of South America and part of Africa, to name a few. From first- to third-world countries, heart disease continues to remain the deadliest disease in the world.

– Nick Magnanti

Sources: International Business Times, WebMD 1, WebMD 2, The New York Times, Medical News Today, AVERT, CDC
Photo: Diseases-Causes-Cure blog