Archive for category: Disease

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How mRNA Vaccines Could Help the World’s Poor

mRNA VaccinesVaccinations have been one of the most successful disease prevention tools the world has ever seen to date; the rise of vaccinations and a decrease in disease mortality go hand in hand. The World Health Organization is cited stating that vaccinations prevent about six million deaths worldwide every year. That number could increase if a new type of vaccine, an mRNA vaccine, proves effective.

Some of the more impoverished nations of the world encounter a variety of setbacks when trying to implement vaccinations on a wide scale. Some populations simply cannot afford vaccines while others living in rural areas may not have access or transportation to reach a medical facility. Further, others still may live in unsanitary environments that allow pathogens to easily thrive and spread throughout their communities. Fortunately, scientists in Germany have been testing mRNA vaccines that could have the possibility of eliminating some of these issues.

Testing mRNA Vaccines

Last year, the Bill & Melinda Gates Foundation partnered with CureVac and BioNTech (two biotechnology corporations) to experiment with new ways to make vaccines. These new vaccines utilize the body’s naturally administered mRNA, which are the molecules that turn genetic information into proteins. In 2018, the companies found positive results while testing these vaccines on both small and large animals.

Later that year, mRNA vaccines designed to combat rabies began phase I of their testing on human participants. The testing took place in Germany and involved 130 participants who had not yet received a rabies vaccine in their lifetime. Then the results of the mRNA vaccine were compared with the results of another treatment.

“The first study participant enrolled in this rabies clinical trial is a significant milestone for CureVac, and allows the company to demonstrate its ability to trigger an immune response in vaccine naïve populations, which is different from vaccines just boosting an already existing immune response such as a flu vaccination,” explained Dan Menichella, CureVac’s CEO.

Implications of mRNA Vaccines

Though the study is not expected to be fully completed until 2021, researchers are finding that mRNA vaccines may be potentially more durable than standard versions of preventative vaccines.

If that is proven to be the case, the implications of how these new vaccines could help the world’s poor are huge. The mRNA vaccines would be able to be developed quickly—quickly enough, it is speculated, to respond to grave infectious disease outbreaks like Ebola. They would also be considerably cheaper to manufacture. And while most vaccination plants cannot be renovated or repurposed to produce other vaccines, only one mRNA vaccine plant could create multiple vaccines that target different diseases.

While mRNA vaccines still have a long way to go in the way of human testing and production, they seem to be off to a good start. It may one day completely revolutionize the way developing countries—or any country, for that matter—vaccinate. And although the medical field is a complicated one, one thing is for certain: CureVac and BioNTech are companies everyone should keep their eyes on for future breakthroughs.

– Haley Hiday
Photo: Flickr

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Naturalin: A Novel Solution for Diabetes and Obesity

solution to diabetes and obesity
Currently, almost 80 percent of diabetes deaths occur in low or middle-income countries. Halo Life Sciences, a company based in Austin, Texas, plans to change that. It has developed a product that it calls Naturalin, a naturally occurring phytonutrient that can go into snack foods, dairy, protein products, beverages and more. The addition of Naturalin makes these products far more nutritious. Naturalin has a massive potential to enact positive change in the food industry in a number of nations around the world as a solution for diabetes and obesity.

Naturalin Basics

Entrepreneur Michael Reyes originally developed Naturalin as a response to the growing number of obese, diabetic and pre-diabetic individuals in developing countries. Island nations such as the Marshall Islands, Tuvalu and Nauru have the highest rates of diabetes in the world. Individuals who are diabetic often contract the disease because their bodies are insulin resistant. Many different things can cause insulin resistance, but it is closely associated with excess weight and body fat. This, in turn, places an undue burden on both these individuals and the health care providers in these countries, as individuals with diabetes often require specific medications, such as short and long-acting insulin, amylinomimetic drugs, alpha-glucosidase inhibitors and DPP-4. Naturalin can help reduce this burden by fortifying common foods such as rice and flour. In addition to its nutritional benefits, Naturalin is a sustainable product and is a renewable resource, ensuring that it will be available for usage by future generations.

Plans for Expansion

Halo Life Sciences is currently in the process of getting Naturalin into markets around the world, including in Brazil, India, China and Israel. The company has partnered with a number of individuals and corporations in these countries. It is also planning to start developing its own CPG’s (consumer packaged goods) that will already have Naturalin in them. These recent developments will likely result in Halo Life Sciences receiving investments from those who see Naturalin’s potential as a solution for diabetes and obesity. Such investments will make the process of expanding into global markets much easier.

Potential Roadblocks

While Naturalin has the potential to enact real global change, it does face some potential roadblocks in the implementation process. For one, a strong marketing campaign must back the product, so that people know about its benefits. Halo Life Sciences has already done some work on this end, as it has invested heavily in scientific research; researches at the University of Texas-Austin validated Naturalin as safe, functional and effective when they tested it. However, it must continue to work on getting its message out to people around the globe. The company must also navigate the oftentimes tricky process of delivering its product into rural communities. If Naturalin can deal with these two potential roadblocks, it will be able to thrive as a product in countless nations around the world.

Changing the World

Naturalin has the capacity to change the world for the better by being a solution for diabetes and obesity. It provides individuals with a quick and easy way to consume more nutritious food, and upon implementation, will almost certainly reduce the total number of individuals suffering from diabetes and obesity worldwide. It is, without a doubt, a very promising solution to one of the most pressing issues facing the modern world.

– Kiran Matthias
Photo: Pixabay

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Enteric and Diarrheal Disease Prevention

Enteric and Diarrheal DiseasesEnteric and diarrheal diseases affect 1.7 billion children around the world every year killing over 500,000 children under five annually. The most common enteric and diarrheal diseases are rotavirus, cholera, shigella and typhoid.

Types of Enteric and Diarrheal Diseases

Rotavirus: Rotavirus is a highly transmittable disease and is one of the main causes of severe diarrhea in children. The disease affects millions of individuals around the world every year and is the cause of death in over 215,000 cases. The disease most often transfers via consumption of fecal matter, which can occur when individuals do not have access to proper handwashing and sanitation facilities. The Rotavirus vaccine can help prevent rotavirus. It is effective in preventing severe rotavirus in 90 percent of cases and the WHO has recommended it for use. Typically, children that are two to six months old receive two to three doses of the vaccine. Individuals who do not receive this vaccine and contract rotavirus (or cholera, typhoid, or shigella) most often receive treatment with either zinc supplementation or rehydration therapy or both. Zinc supplementation can reduce the severity of diarrhea in an individual while oral rehydration therapy can help rehydrate an individual that has become dehydrated due to diarrhea.

Cholera: Cholera is another diarrheal illness that individuals can contract by consuming contaminated food or water. It affects roughly three million individuals around the world every year and is the cause of death in nearly 145,000 cases. Furthermore, there have been recent outbreaks in countries like Haiti, Sierra Leone, Zimbabwe and Guinea. Like rotavirus, a specialized vaccine can prevent cholera as well as sound sanitation techniques. Individuals older than six receive the vaccine in two doses while younger individuals receive three doses.

Typhoid: Like rotavirus and cholera, typhoid is transmitted through fecal contamination. It affects 22 million people annually and is the cause of death in roughly 200,000 cases per year. Before recently, no one had developed a vaccine to treat typhoid; however, in 2018, the WHO approved a vaccine called Typbar TCV. Scientists from Bharat Biotech International, a biotechnology company based in Hyderabad, India, developed the vaccine. Hundreds of thousands of individuals have received the vaccine and it has played a key role in stemming a recent typhoid breakout in Pakistan.

Shigella: The last major form of an enteric/diarrheal disease is shigella. Over 165 million individuals contract shigella every year (causing one million deaths), in large part due to the fact that there is no preventative vaccine for the disease. Because of this, much of the effort that has been given to prevent Shigella recently (as well as rotavirus, cholera and typhoid) have focused on ensuring proper hygiene and sanitation in areas that are at risk for fecal contamination. Listed below are some promising solutions to improve hygiene and sanitation in developing countries around the world.

Solutions to Reduce Enteric and Diarrheal Diseases

Janicki Omni Processor (JOP): The Janicki Omni Processor is an innovative solution that can help turn waste into clean drinking water. To do so, wet waste enters the JOP which dries and burns the waste in a controlled fashion. The JOP filters and condenses the resulting steam from the burning process, distilling the water. This water then receives treatment in order to meet clean drinking water standards. The JOP is environmentally friendly (the entire process is self-sustainable) and, through heavy funding from NGOs such as the Bill and Melinda Gates Foundation, it is a cheap and efficient way to provide clean water to communities throughout the developing world.

Nano Membrane Toilet: The Nano Membrane Toilet is a promising solution with regards to sanitation practices throughout the developing world. The toilet is sustainable and requires no water or electricity to function. It works like this: after an individual uses it, the toilet utilizes a waterless flushing system to separate the urine from the feces. The feces are then chopped up into small bits and placed into a combustion chamber. After roughly a week, the feces will turn into a substance similar to ash and people can safely deposit it in the trash. The water, meanwhile, enters a separate tank to purify. The purified water then enters a tank at the front of the toilet for the purpose of outdoor irrigation and cleaning. The Nano Membrane Toilet is a promising solution to help reduce feces contamination because it does not require water to function and is easily implementable in many communities around the world.

Hand Washing: Hand washing isn’t a new technology, but it can go a long way towards preventing a multitude of enteric and diarrheal diseases. Research indicates that diarrheal deaths could decrease by as much as 50 percent if the prevalence of handwashing increased around the globe. NGOs such as The Global Handwashing Partnership and World Vision have done great work in recent years to lead handwashing programs in developing nations and increase awareness about the importance of handwashing.

Looking Ahead

The prevention and treatment of individuals with rotavirus, cholera, typhoid and shigella are some of the biggest challenges facing the world in the coming years. The transmittable nature of these diseases makes them difficult to eradicate, and people cannot fix many of the reasons that they are prevalent (lack of sanitation, poor water quality, etc.) overnight. Continued investments from governments and NGOs around the world in promising technologies like the Janicki Omni Processor and the Nano Membrane Toilet are a step in the right direction towards the prevention of enteric and diarrheal diseases in individuals around the world.

– Kiran Matthias
Photo: Pexels

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15 Worst Earthquakes and the Human Toll

worst earthquakes and the human toll
While the death toll and size of an earthquake can provide logistical data, other factors influence the devastation victims face and the rate they can recover. For communities already struggling, these disasters can be particularly devastating. Ranked below are the 15 worst earthquakes and the human toll of each.

15 Worst Earthquakes

  1. Haiti (2010): At the top of the list of 15 worst earthquakes and the human toll, Haiti suffered an initial 7.0 magnitude quake followed by two aftershocks killing 316,000 people. Due to a lack of adequate reinforcement, buildings across the country crumbled. A loss of power and phone lines interfered with efforts to provide aid. After nine years, Haiti still attempts to repair itself.
  2.  Nepal (2015): After crumbling landmarks and 10-story buildings, a 7.8 magnitude earthquake added landslides and avalanches to its path of destruction. An estimated 9,000 citizens died and 22,000 more suffered injuries. More than 600,000 people lost homes and began facing extreme poverty. However, its government and humanitarian organizations responded quickly. Temporary education centers and shelters helped the displaced, and over the last three years, facilities are recovering.
  3. Sumatra, Indonesia (2004): The 9.1 magnitude disaster in the Indian Ocean produced severe casualties and devastation. The earthquake itself likely killed 1,000 but the tsunami that followed left 227,898 dead or missing. Because of the short time span between the earthquake and tsunami, no one could create separate death tolls. Indonesia had damages of $4.4 million.
  4. Sichuan, China (2008): Whole villages lay flattened after a massive 7.9 quake. Schools and other facilities collapsed, trapping people inside. Estimates determined there were around 90,000 dead, 5,300 of them being children attending class. Buildings injured an estimated 375,000 more citizens and rescue teams attempted to find missing children after the chaos.
  5. Tohoku, Japan (2011): An unfortunate 15,703 deaths occurred after an earthquake and tsunami struck the east coast of Japan. The total economic loss racked up to $309 billion to provide reconstruction and services. A nuclear power plant near Okuma suffered damages to its reactors, causing a radiation leak. Thanks to evacuation efforts, the leak did not harm anyone. Several fires occurred after and the event destroyed docks.
  6. Izmit, Turkey (1999): Lasting less than a minute, an earthquake striking southeast Izmit left 17,000 dead and 500,000 homeless. Thousands of buildings and an oil refinery were among the destruction. There was a large outcry of people persecuting contractors for their poor workmanship and their use of cheap materials. Authorities found very few of them guilty, however. The 7.4 magnitude earthquake caused an estimated $3 to 6.5 billion in damages.
  7. Rudbar, Iran (1990): A 20,000 square mile earthquake devastated homes and farms at midnight. An estimated 50,000 people died and 135,000 injured, some living in simple houses that lacked support. An aftershock the following day caused a dam to burst, adding to financial losses and further loss of farmland. Estimates determined that the reconstruction of the region cost $7.2 billion.
  8. Kashmir, Pakistan (2005): Kashmir, the disputed area between India and Pakistan, suffered a loss of 80,000 people after a magnitude 7.6 earthquake. Four million others became homeless. Sections of towns completely slid off sides of cliffs; landslides also created a blockade for relief workers. In addition, the fact that it occurred just before winter worsened the conditions of those seeking shelters.
  9. Mexico City, Mexico (1985): Mexico City fell to chaos when 400 buildings crumbled, and the power and phone systems blacked out. Public transportation also halted, leaving panicked citizens without communication or instructions. An estimated 250,000 people were without shelter, and a final death count totaled 10,000.
  10. Yunnan, China (2014): Around 4.7 in magnitude, this earthquake killed 398 citizens. The earthquake injured an estimated 1,000 people and displaced over 200,000. Several homes and infrastructure susceptible to earthquakes faced damages as well. The Committee for Disaster Reduction had issued its highest-level response to provide aid: emergency responders prioritized search-and-rescue and the organization directly allocated resources for this purpose.
  11. Puebla, Mexico (2017): A 7.1 magnitude earthquake struck central Mexico on the anniversary of its 1985 earthquake. Since the 1985 quake, people underwent earthquake drills which helped limit the damage in the 2017 earthquake although 225 deaths still occurred. Additionally, the earthquake damaged buildings and Mexico had to evacuate its people. Nearby, homes had also crumbled.
  12. Norcia, Italy (2016): After suffering multiple previous quakes in a short timeframe, another 6.2 magnitude earthquake occurred between two towns: Norcia and Amatrice. Numerous aftershocks, magnitudes 5.5 through 7 then followed. Because of its unfortunate location between cities and mountain villages, the quake took 247 victims. Rubble from mountains trapped others and blocked roads.
  13. Ecuador (2016): After this earthquake, 100,000 people needed shelter, 6,000 suffered severe injuries and 700 died. The earthquake destroyed schools and homes along with health care facilities. Flooding following the crisis worsened an outbreak of the Zika virus, but World Vision helped lessen its impact. It provided information on mosquito control and provided activities to teach sanitation in order to prevent the spread of Zika.
  14. Balochistan, Pakistan (2013): The largest province in Pakistan, Balochistan felt an immense tremor from an earthquake with a 7.7 magnitude. Awaran, one of six districts affected, lost 90 percent of its houses. The death toll stood at 328 with more than 440 wounded. Excessive mud that the earthquake brought in buried food, water and houses.
  15. Chile (2010): In 2010, a severe 8.8 magnitude earthquake damaged 400,000 homes. Copper production, crucial to Chile’s economy, halted until power resumed. Including loss of exports, the damages totaled $30 billion. The government estimated that the earthquake directly affected 2 million people, while another 800 had died.

Sporadic and unrelenting, earthquakes affect both coastal and inland areas. However, all of the 15 worst earthquakes and the human toll experienced in each have a uniting factor in that they received aid. Despite the severity, government programs and humanitarian bodies rushed to the scene, supplying temporary homes and rations to those suddenly without a place to live. Also, even though most major cases take years to restore themselves, organizations and governments often do not stop giving aid.

– Daniel Bertetti
Photo: USAID

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Azithromycin Could Help Ethiopian Children

Helps Ethiopean ChildrenAfrica has the highest child mortality rate of any continent. Ethiopia sits in the middle of the child mortality ranking of countries throughout Africa with 59 out of 1,000 children dying before the age of five. While it is not as high as the rate of 76 per 1,000 children found in sub-Saharan Africa, it is much worse than many developed nations, which average around 6 deaths per 1,000 children annually. New research, however, shows that childhood mortality can be significantly lowered in Africa using an antibiotic that could help Ethiopian children prevent blindness.

Azithromycin Helps Ethiopian Children

Trachoma is the leading bacterial infection that causes blindness. In an effort to lower the number of cases of trachoma, researchers preemptively gave azithromycin, an antibiotic effective at fighting trachoma, to thousands of children under the age of nine in Ethiopia. The researchers administered these doses of azithromycin to children twice a year.

After observing the children for several years, they came to a shocking discovery: azithromycin will help Ethiopian children live longer. Not only did the bi-annual antibiotic prevent against trachoma, as the researchers believed it would, but it also protected against many other common ailments as well. For those children in the case study, the childhood mortality rate was cut in half.

The discovery seemed too good to be true, so this group of researchers tried to replicate their findings in other African nations with higher child mortality rates. Close to 200,000 children were given azithromycin in Tanzania, Malawi and Niger. While the results were not quite as impressive as cutting the child mortality rate in half, as seen with Ethiopia, the results were still high. The twice-yearly drug lowered child mortality rates between 14 to 19 percent in each country.

Research Into Other Illnesses

Research must continue before Africa will see widespread use of azithromycin for children. If approved for widespread use, this antibiotic could help prevent some of the common illnesses that lead to child mortality. These common illnesses include:

  • Pneumonia: Pneumonia kills nearly 100,000 children per year in Africa. This accounts for 16 percent of childhood death under the age of five. Currently, when children contract pneumonia, only one third are able to receive lifesaving antibiotic treatment.
  • Diarrhoeal disease: Diarrhea is the leading cause of death in children under the age of five. Diarrhea is a common infection in the bowels. It is completely preventable and treatable, yet it is estimated that 525,000 children in Africa die annually from this illness.
  • Malnutrition: Malnutrition contributes to childhood mortality rates. While the use of azithromycin will not be able to prevent malnutrition, it may be able to help prevent other ailments that the body is not able to fight off because of the lack of nutrients and calories.

Long term effects of azithromycin used to prevent ailments in children are not known. However, the studies have shown promising results in saving the lives of hundreds of thousands of African children. With a few more years of research and more funding, these researchers may be able to permanently lower the childhood mortality rate in Africa. Not only will this research continue to help Ethiopian children but it will also help children of other nations, ensuring they live into adulthood.

– Kathryn Moffet
Photo: Pexels

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New Innovation to Transport Fragile Vaccines

Fragile Vaccines

Researchers at McMaster University in Ontario, Canada, have developed a possible breakthrough with regards to the storage of certain fragile vaccines. They have found a way to protect these vaccines from direct heat, negating the need for them to be stored in a cool environment. The implications of this innovation are massive. If organizations like Health Canada approve it, the reach of vaccinations to rural areas will increase, and with that, disease and sickness should decrease.

Coating on Vaccines

The researchers found that placing a gel-like coating over the vaccines was the best way to protect them from the heat. To make this coating, researchers mixed two sugars, trehalose and pullulan, with the vaccine and let it dry. As the sugars dried, the researchers coated the vaccine, making it resistant to heat and rendering the cold chain (the process of storing vaccines at temperatures ranging from 2 C to 8 C) unnecessary. Heat resistance is important because many people living in more rural areas of the world do not have access to refrigeration. Now, individuals living in impoverished areas will have access to a number of vital vaccines, helping protect them from diseases such as Ebola and influenza.

The technology’s development was the result of countless years of testing and hard work. But it is clear that the end product will be more than worth the time spent. When asked about the significance of the technology, Vincent Leung, an Assistant Professor of Chemical Engineering at McMaster and one of the masterminds of the testing, said that it is “very exciting that something we worked on in the lab has the possibility of saving people’s lives one day.” Leung has reason to be proud; the technology is filling a clear need and will undoubtedly have a massive impact upon its implementation.

What Happens Next

Health Canada and the U.S. Food and Drug Administration must still provide approval for the new technology. These organizations will analyze the effectiveness, practicality and safety of the technology. These organizations are likely to approve it because both have already accepted trehalose and pullulan.

The researchers have received funding from many organizations around the world, including the Bill and Melinda Gates Foundation. They are now working with commercial partners in an effort to get the technology to market upon approval. Once accepted, it will likely see heavy usage in more rural parts of the world, such as in many regions of Africa. In many of these areas, individuals do not receive vaccinations for preventable diseases. In fact, more than 7.6 million children in Africa are not vaccinated each year.

This new innovation to transport fragile vaccines has immense potential to shape the future in a positive way. Vaccines will now become cheaper and more efficient to transport around the world. In addition, as more individuals obtain vaccinations, rates of disease and poverty should decrease and life expectancy should increase. While there are still many steps for this new technology to take before implementation, the promise of the technology provides immense hope.

– Kiran Matthias
Photo: Flickr

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Health Crisis: Measles Outbreak in the Philippines

Measles Outbreak in the PhilippinesIn January 2019, a measles outbreak in the Philippines began, leaving more than 450 dead and over 33,000 cases to date. Fifteen years after the near eradication of measles in the Philippines, the disease has returned with a vengeance in the Southeast Asian nation. The vaccination rate for measles in the Philippines has declined steadily, from more than 80 percent in 2008 to under 70 percent in 2017.

Several factors have led to a steady decline in the vaccination rate over the last decade. The issue of accessibility affects many people in rural areas of the country, putting them at risk of contracting diseases that are easily preventable with vaccination. The Philippines consists of 7,000 islands and does not have a secure health care budget in place, rendering it nearly impossible to ensure that all citizens are vaccinated.

Increasing misinformation concerning the negative side effects of vaccines has led many people to become skeptical about vaccinating themselves and their children. This drop in confidence in vaccinations has been quite significant. A 2018 study found that nearly 100 percent of participants were in favor of vaccines in 2015, believing them to be safe and effective only four years ago.

Who is at Risk?

Anyone who is not regularly vaccinated is at risk of contracting measles. The airborne virus can spread extremely easily and remains in a room for hours after an infected person has coughed or sneezed. The measles outbreak in the Philippines has affected thousands of people, including many young children who were not given the proper vaccination. Children under six months of age are especially in danger of contracting measles, as they are too young to receive the vaccine.

Pregnant women or those planning pregnancy run additional risks if they are not vaccinated against measles. If a woman wants to become pregnant — and is vaccinated beforehand — she should wait at least four weeks before attempting to conceive. This ensures that the vaccine is functioning properly and effectively. If a woman is not vaccinated against measles and becomes pregnant, a variety of side effects can occur. Common reactions include premature birth, miscarriages or stillbirths, and babies born underweight.

What Can be Done?

Fortunately, the growth rate of the measles outbreak seems to be slowing. New cases decreased to a few hundred per week in May, while thousands were infected each week in February and March. The decline in new cases largely due to local health officials visiting communities firsthand and checking residents’ vaccination statuses.

For children under six months of age who are unable to receive the necessary MMR (measles, mumps, and rubella) vaccine, the best precaution is to limit contact with anyone who is not a primary caregiver. Infants aged six to 11 months should have one dose of the vaccine, while children over one year and adults should have two doses of the vaccine given at least 28 days apart.

A Bright Side to the Measles Outbreak in the Philippines

Despite the tragic number of families that have been affected by the measles outbreak in the Philippines, there is a bright side. Since the outbreak began in early 2019, more than five million people have been vaccinated against the disease. The Filipino government hopes to boost that number to 20 million by the fall, which would mean one-fifth of the country’s population would be newly vaccinated this year. By immunizing such a significant percentage of the population, the Philippines can restore faith in the healthcare system, and prevent further illness and death.

– Emi Cormier
Photo: NPR

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Bangladesh Winning the War Against Diarrhea

Bangladesh Winning the War Against Diarrhea

Despite being a developing country, Bangladesh has made exceptional progress in its health sector. It is reducing its infant mortality, increasing life expectancy and working to maintain control over diseases. Its progress in reducing life-threatening diarrhea is yet another triumph for the country’s health sector and its various interventions. Below are some indicators of Bangladesh winning the war against diarrhea.

Reduction of Diarrhoeal Deaths for Infants

Between 2000 and 2016, Bangladesh had managed to reduce the number of diarrhea-related deaths for children under five by 81.8 percent from 38,877 to 7,062 deaths. Oral Rehydration Therapy (ORT) has had a significant impact on reducing diarrhea in children in Bangladesh. In 2011, the country had a 90 percent reduction rate from the last 30 years after an increase in ORT.

From 1993 to 2014, the proportion of children diagnosed with diarrhea receiving either Oral Rehydration Salts (ORS) or Recommended Homemade Fluids (RHF) increased from 67 percent to 89 percent in urban areas and 58 percent to 83 percent in rural areas. As of 2015, diarrhea accounted for only 2 percent of under-five deaths, compared to around one-fifth in the 1990s.

As the pioneer in effective diarrhea control, The International Centre for Diarrhoeal Disease Research, Bangladesh has been saving lives since the 1960s. It strongly promotes the use of ORS. Through a national program, Bangladesh became the first country to increase oral rehydration therapy. It treats more than 100,000 people each year for diarrheal diseases and related nutritional and respiratory problems.

The center was also involved in research that showed how zinc supplements could not only reduce the duration of diarrhea but also lessen the risk of recurrence. It has increased its efforts in providing more zinc tablets to children in need.

Ending Preventable Child Deaths by 2035

This initiative was launched by the Ministry of Health and Family Welfare (MOHFW) of Bangladesh, along with other civil society organizations and professional associations. The goal of this initiative has been to reduce child deaths to 20 per 1,000 live births by 2035 largely by cutting down under-five mortality and reducing the neonatal mortality rate.

Bangladesh has performed very well before the target date. Bangladesh has made remarkable progress in maternal, newborn and child survival interventions. Other than providing vaccines and skilled birth attendants, interventions under this initiative also include changing social norms like open defecation given the role it plays in causing diarrhea. This further contributes to Bangladesh winning the war against diarrhea.

Integrated Management of Childhood Illness (IMCI)

Adopted in 1998, the IMCI program finally launched in 2002. This program focuses on the major causes of child mortality such as diarrhea, pneumonia, malaria, measles and malnutrition. As of 2015, the facility-based IMCI program has been implemented in 425 of the 482 sub-districts across the country, including community clinics.

By 2013, more than “4000 doctors, 17,000 paramedics, 8,500 basic health workers and 15,600 skilled birth attendants” were trained under this program. The number of trained healthcare workers providing quality care for sick children increased from 8 percent to 24 percent between 2002 to 2009 as a result of this program.

Strong Network of Community Healthcare Workers and Volunteers

The government’s strong network of community healthcare workers and volunteers has played an important role in Bangladesh winning the war against diarrhea. These healthcare workers and volunteers have been able to quickly identify and treat diarrhea cases at the community level and send the most serious cases to local clinics for more intensive treatment. This allows for quick identification of symptoms, and as a result, it enables fast responses that can help prevent epidemics.

Other than these interventions, improvements in access to clean drinking water and sanitation have also immensely contributed to Bangladesh winning the war against diarrhea. Despite the level of poverty, it is commendable how far Bangladesh has come in terms of vanquishing diarrhea.

– Farihah Tasneem
Photo: Flickr

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Southeast Africa Combats the Cyclone Idai Health Crisis

Cyclone Idai Health CrisisOn March 14, 2019, disaster struck southern Africa in the form of Cyclone Idai, a category 2 tropical storm that ravaged through Mozambique, Malawi and Zimbabwe. Idai made landfall in Beira, Mozambique, a large port city of more than 530,000 citizens. The International Federation of Red Cross and Red Crescent Societies asserts that 90 percent of Beira has been destroyed in the wake of Idai. The subsequent Cyclone Idai health crisis continues to challenge Southeast Africa.

As Idai strengthened along the coast of Africa, Mozambique and Malawi experienced severe flooding resulting from heavy rainfall. The cyclone destroyed roads and bridges, with a death toll of 1007. Hundreds more are still missing. Sustained winds of over 150 mph damaged the crops, homes and livelihoods of thousands throughout southeast Africa. To top it all off, Mozambique, Malawi and Zimbabwe are experiencing a major health crisis in southeast Africa in the aftermath of Cyclone Idai.

Cholera and Malaria

As of May, more than 6,500 cases of cholera have been reported. This intestinal infection is waterborne, commonly caused by drinking unsanitary water. In Mozambique, a country already vulnerable to poverty, the cholera outbreak exacerbates the adverse effects of Cyclone Idai. Cholera can be fatal without swift medical attention, though prompt disaster relief response and a successful vaccination campaign made significant strides in containing the outbreak.

In addition to cholera outbreak, cases of malaria are rising, with nearly 15,000 cases reported since March 27. Malaria is transmitted through Anopheles mosquito bites, insects that flourish in the standing flood waters of Idai. According to WHO, almost half of the world’s population is at risk of malaria, with the majority of cases and deaths in sub-Saharan Africa. Relief efforts prepared for the outbreaks by arming health professionals with antimalarials and fast-acting diagnostic tests.

Cyclone Idai Health Crisis Relief Efforts

The health crisis in Southeast Africa following Cyclone Idai received swift aid response. Disaster relief efforts prepared vaccinations and medications beforehand, ensuring that medical response was efficient and effective. The total recovery cost for the damage inflicted on Mozambique, Malawi and Zimbabwe is estimated at over $2 billion. The tropical storm affected upward of three million Africans.

WHO delivered 900,000 doses of oral cholera vaccine retrieved from the global emergency stockpile. Further, the organization plans to create multiple cholera treatment centers in hopes of containing the outbreak. World Vision is concentrating their efforts on the spread of this infectious disease. The humanitarian aid group is working alongside UNICEF to distribute cholera kits with soap and water purification tablets.

Rapid aid efforts also met the spike in malaria cases to combat the Cyclone Idai health crisis. WHO secured 900,000 bed nets treated with a strong insecticide to prevent the spread of the mosquito-borne disease. However, children and infants are at major risk, as malaria is considered the third most deadly disease to this population. The hefty humanitarian response and support necessary to help Mozambique, Malawi and Zimbabwe has prompted UNICEF to launch an appeal for $122 million for the next nine months.

-Anna Giffels
Photo: Pixabay

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Fighting Breast Cancer in Developing Countries

Breast Cancer in Developing CountriesWomen in developing countries lack access to safe and cost-effective breast cancer screening practices, leaving cancer frequently undetected. As a result, three times as many women in low-income, developing countries die each year due to breast cancer compared to developed countries. A team of young women from John Hopkins University is working to change this disparity and save lives through the creation of a new biopsy device.

Early Detection: A Better Chance for a Cure

Great strides have been made in the prevention and treatment of breast cancer in developed countries. More than 80 percent of women diagnosed in North America, Sweden and Japan survive. However, the situation is far different for women in the developing world. Less than 40 percent of women diagnosed in developing countries survive the disease, according to the WHO. This disparity in fatalities can be attributed to a lack of early detection. Studies in Europe and Canada found that the risk of breast cancer death decreased by more than 40 percent among women who underwent early diagnostic screening. In the U.S., data reveals the widespread use of early detection procedures and a 39 percent decrease in U.S. breast cancer fatalities after the 1990s.

Screening for Breast Cancer in Developing Countries

In 2003, the World Health Survey found that only 2.2 percent of women aged 40 to 69 years received breast cancer screening in low- to middle-income nations. More than half of women newly diagnosed with breast cancer in those nations have already progressed to stage III or IV disease. In the United States, 71.5 percent of women aged 50-74 have been screened within the past two years and over 90 percent of recently-diagnosed women have locoregional breast disease.

Why Aren’t Women Screened?

One of the main factors preventing women in low- to middle-income countries from early breast cancer detection is the high cost of screening procedures. Core needle biopsy (CNB) is a common diagnostic procedure that allows doctors to test a sample of breast tissue from the area of concern. In high-income countries, doctors use efficient and expensive disposable CNB drivers for breast biopsies. Low-income countries often cannot afford the same expense, relying instead on reusable drivers. These drivers are easily contaminated and the cleaning process is extremely time-consuming and costly, rendering breast cancer biopsies unavailable to most women in developing countries.

Ithemba: Hope for Women with Breast Cancer

A group of Johns Hopkins undergraduates won a 2019 Lemelson-MIT Student Prize for their creation of a safe, low-cost, reusable breast cancer biopsy device. After learning of the unsafe and inefficient diagnostic methods in developing countries, the team of four young women set out to create a safe and cost-effective CNB driver. Their device is named Ithemba, the Zulu word meaning “hope.” the CNB driver is centered around increasing women’s access to early breast cancer diagnosis. The device’s disposable needle contains a chamber that traps contaminants and is easily sterilized with a bleach wipe, ensuring safe reuse. Ithemba is expected to last up to 20 years before replacement is necessary.

The Johns Hopkins students have conducted over 125 stakeholder interviews. They predict that within the first five years on the market, Ithemba will impact the lives of 300,000 women in developing countries. In May of 2018, the team filed for a patent and are now searching for low-cost manufacturing methods and finalizing estimated costs.

Valerie Zawicki, one of the four undergraduates on the team, insists that the location of a woman’s home should not determine her odds of surviving cancer. The mission of Ithemba is to give all women—no matter where they live—hope with the chance to fight and survive breast cancer.

– Sarah Musick
Photo: Wikimedia