Nanoly: Delivering Vaccines to Developing Countries

In the developed world, vaccines are readily available: they are kept refrigerated until they are needed in a doctor’s office or in a hospital. Unfortunately, delivering vaccines to developing countries is a big issue that needs to be addressed. Nanoly, a bioscience company, hopes to address the issue of vaccine transportation without refrigeration, through the use of its revolutionary polymer called NanoShield.

The proteins within a vaccine need to have a controlled environment to survive, thus, controlling storage temperature is the most important factor. The polio, measles and tetanus vaccines all need to be kept within a 35-45 degrees Fahrenheit temperature. These are also some of the most important vaccines that developing countries need.

If the vaccines are not stored in that temperature range, the proteins in the vaccine cease to function, rendering the vaccine useless.

The current “cold chain” method of delivering vaccines to developing countries requires the use of a chain of cold storage units that maintain the optimal temperature for vaccines during transport. However, the cold chain becomes difficult to maintain when it gets closer to rural areas due to the lack of electricity.

Nanoly’s creation is a new way to keep the vaccines temperature regulated and is more reliable than the cold chain. By blending the proteins with NanoShield, the polymer protects the proteins in the vaccines from outside temperatures.

During tests with high temperatures over a two week period, vaccines with NanoShield had an 88 percent efficacy rate while vaccines without it had only an 18 percent efficacy rate. The NanoShield protected the proteins and a large number of the vaccines were still usable. NanoShield can be applied to anti-viral vaccines, antibody drugs and therapeutics to help keep the temperature regulated.

It seems that there are also no adverse reactions to the polymer as well. Not only does the polymer protect the proteins from deteriorating due to high temperatures, it also does not need to be removed to administer the vaccine.

Delivering vaccines to developing countries can be difficult due to the lack of electricity. Thanks to Nanoly and their NanoShield polymer, delivering the vaccines becomes much more viable.

Developing countries need these vaccines to help protect their citizens from diseases like polio and measles. Nanoly can potentially save millions of lives thanks to the polymer they have developed.

– Daniel Borjas

Photo: Flickr

The Eliminate Project Helps Mothers and Newborns in Poverty

Maternal and neonatal tetanus or MNT is responsible for the deaths of 50,000 babies a year in developing countries. So, Kiwanis International joined the United Nations Children’s Fund (UNICEF) to eliminate this disease with the Eliminate Project. In June 2010, Kiwanis announced the Eliminate Project at the 95th Annual Kiwanis International Convention and pledged to eliminate MNT from mothers and newborns in poverty by 2015.

The Eliminate Project’s goal is to raise money for vaccinating pregnant women whose babies might be at risk of MNT. MNT is caused by bacteria found in the soil of developing countries. The disease spreads through unhygienic birthing practices and causes intense pain to the newborn, killing the baby within five to six days.

However, MNT is easily preventable if the mother takes three doses of the Tetanus Toxoid-Containing Vaccines (TTCV). The solution is cost-effective too; the total cost of these doses is only $1.80.

UNICEF has made excellent progress to combat this disease with 90 percent of its funds going directly to the cause. Kiwanis has also made progress by raising $110 million for the Eliminate Project with many fundraising projects. According to the World Health Organization, the number of newborns in poverty dying of neonatal tetanus went from 787,000 in the late 1980s to only 34,019 in 2015.

Kiwanis and UNICEF have been successful in decreasing the prevalence of the disease in a number of countries, but there is still more work to be done. There are mothers and babies in 19 countries in Africa, Asia, Europe and North America who are contracting the disease with little to no healthcare. On a positive note, there are 13 countries that scheduled immunization campaigns in 2016, and Kiwanis clubs around the world are relentlessly raising money to eliminate MNT once and for all.

– Emma Majewski

Photo: Flickr

Drones Now Delivering Lifesaving Vaccines

Deploying unmanned drones in low and middle-income countries could save money and increase vaccination rates, according to new research conducted by the Johns Hopkins Bloomberg School of Public Health and the Pittsburgh Supercomputing Center.

Many low- and middle-income countries struggle to deliver lifesaving vaccines to sick people who are fighting preventable diseases.

Bruce Y. Lee, director of operations at the International Vaccine Access Center at the Bloomberg School says “[We] make all these vaccines but they’re of no value if we don’t get them to the people who need them. So there is an urgent need to find new, cost-effective ways to do this.”

Currently, vaccines such as hepatitis B, tetanus, measles and rotavirus are typically transported by road through two to four storing sites before they reach clinics where the doses are finally administered to patients. The majority of vaccines require refrigeration until they are used or else they will spoil.

In addition, non-vaccine costs of routine immunization are expected to rise between 2010 and 2020, mostly derived from supply chain logistics.

In the meantime, unmanned drones have proliferated. They can traverse all land and topography, decrease labor costs and substitute the need for vehicle transportation. They have been heavily used for surveillance and in humanitarian aid delivery.

A study conducted at Johns Hopkins University found that utilizing drones to transport vaccines to their final destination could slightly increase the rate of immunization, immunizing 96 percent of the target population as compared to 94 percent using land-based transport. This simultaneously produced significant savings, eight cents for every dose administered (roughly 20 percent savings).

“Assuming the drones are reliable, are capable of making the necessary trips and have properly trained operators, they could be a less expensive means of transporting vaccines, especially in remote areas,” says Lee. He adds, “They could particularly be valuable for urgent orders.”

An initiative led by the United Parcel Service Foundation and Gavi, the Vaccine Alliance, has raised $800,000 grant to support the launch of a zip line drone project in Rwanda that will commence later this year. The government of Rwanda will use zip line drones to make 150 life-saving blood deliveries per day to 21 transfusing facilities in western part of the country.

According to Dr. Seth Berkley, CEO of Gavi, the Vaccine Alliance, “It is a totally different way to deliver vaccines to remote communities and we are extremely interested to learn if UAVs can provide a safe, effective way to make vaccines available for some of the hardest-to-reach children.”

The Rwanda drone network has been initially focused on delivering blood supplies, but plans to expand to include vaccines and treatments for HIV/AIDS, malaria and tuberculosis.

In rural Virginia, Bhutan and Papua New Guinea, drones are currently being tested for medical supply deliveries. UNICEF is also testing their viability of use in Malawi and in Tanzania.

– Sarah Poff

Photo: Pixabay

Tackling Meningitis in Africa with MenAfriVac

On Feb. 22, 2016, vaccine experts from all over the world convened in Ethiopia with leaders from the 26 African “meningitis belt” countries to celebrate the success achieved by MenAfriVac, a vaccine created for use in Africa.

The vaccine was developed specifically for Africa and targets meningococcal A meningitis, a bacterial infection of the thin lining surrounding the brain and spinal cord. Meningitis is a highly-feared disease due to its capacity to kill its host within hours. Survivors often experience permanent hearing loss, paralysis or even mental retardation.

“We have achieved something truly historic with MenAfriVac®—creating an affordable, effective, tailor-made vaccine for Africa,” said Steve Davis, president and CEO of PATH, a nonprofit global health organization.

According to PATH, more than 90 percent of meningitis epidemics in Africa attacked mostly infants, children and young adults. To zero in on this specific cause of meningitis, PATH partnered with the Meningitis Vaccine Project and the World Health Organization (WHO).

In the five years that MenAfriVac has been in effect, 235 million children and adults have been vaccinated. From 250,000 cases during an epidemic from 1996 to 1997, to only 80 confirmed cases in 2015, the vaccine has effectively protected millions of people.

However, a resurgence is possible within 15 years if an immunization program is not implemented permanently. Several countries applied for funding to begin implementing MenAfriVac into their national childhood immunization programs. Gavi, a global health partnership that focuses on vaccines, has spent $367 million campaigning and stockpiling the vaccine since 2008 to support these countries.

“Meningitis A was a scourge across Africa’s meningitis belt for generations but today we can be proud that a safe, effective meningitis vaccine is protecting hundreds of millions of people from death and disability,” said Dr. Seth Berkley, Gavi CEO. “But we must not be complacent. It is critical that at-risk countries begin introducing this vaccine into their routine schedules and ensuring every child is reached and protected.”

This achievement could not have been possible without the vital partnerships that contributed to the development of the vaccine. U.S. agencies financially supported MenAfriVac, provided technical expertise and participated in clinical studies of the vaccine.

Continued partnerships could lead to solutions for other diseases around the world and have a positive impact on global health.

– Emily Ednoff

Sources: Gavi, PATH
Photo: Flickr

Study Finds Inhalation of New Ebola Vaccine Kills Virus in Monkeys

A recent study published by the Journal of Clinical Investigation has reported that a new prototype aerosol Ebola vaccine was found to successfully neutralize the deadly virus within monkeys during clinical test trials.

The study, led by Dr. Michelle Myer and conducted collaboratively by the National Institutes of Health and the University of Texas Medical Branch in Galveston, determined that the experimental vaccine activated immune cells within the respiratory system that subsequently provided full protection against the virus. The study also notes that this is the first time researchers have attempted to use an aerosol vaccine within monkeys to fight a hemorrhagic viral fever such as Ebola.

Co-author of the study Dr. Alexander Bukreyev, a medical virologist from the University of Texas Medical Branch in Galveston, recently stated, “This is one of the few vaccines that works. The initial several decades of attempts to develop a vaccine against the Ebola virus were unsuccessful.”

Vaccination researchers within the medical community have become familiar with the notion of failure, as an experimental drug designed to treat Ebola patients proved ineffective in fighting the virus. The experimental drug, known as TKM-Ebola-Guinea, was designed by Tekmira Pharmaceuticals and reportedly was, “Not likely to demonstrate an overall therapeutic benefit,” for patients infected wit Ebola.

The drug was designed to utilize RNA interference, a process in which the functions of certain genes within the Ebola virus are disrupted and subsequently renders the virus incapable of attacking human cells. Prior to the failure of the trials within human subjects, many researchers considered the experiment the single most promising lead in the race to stop Ebola, as the drug had proved effective in stopping the virus in monkeys during clinical test trials

Since the unprecedented outbreak of the disease in West Africa last year, the virus is estimated to have killed over 11,000 people and infected an additional 27,000 people in the nations of Sierra Leone, Liberia and Guinea, according to the World Health Organization .

As the aerosol vaccine does not require the assistance of trained medical professionals, the distribution of the vaccine within developing regions that lack adequate health infrastructures and large personnel staffing will prove to be notably less challenging. Dr. Igor Lukashevich, a medical virologist from the University of Louisville, recently argued that, “This aerosolized form of the vaccine is really what the field needs right now. The discussion […] right now is if this Ebola outbreak will be some kind of game changer for vaccine development, or will it only be one more scare that will be forgotten.”

Dr. Meyer explained in a recent interview that human cells “in the lungs are acting as the first barrier for protection. That’s ideal to combat the virus at the site of the infection.”

Four of the monkeys used for the study were given a single dose of the vaccine, while an additional four were given two doses of the vaccine. Two other monkeys were given a liquid form of the vaccine, while two more monkeys were not vaccinated in order to serve as controlled variables for the study. Four weeks after the administration of the vaccines, all 12 of the monkeys were administered 1,000 times the fatal dose of the Ebola virus.

Two weeks after the injection of the Ebola virus into the test monkeys, all of the vaccinated monkeys had remained healthy while the two unvaccinated monkeys became infected with the disease and were euthanized.

Dr. Daniel Bausch, a medical virologist of Tulane University, noted that the study was “a positive step forward,” but cautioned that “it’s not a breakthrough or ‘Eureka!’”

The success of the aerosol vaccine during the clinical trials on the monkeys indicates the next step will now be for testing to begin on humans in the coming months.

– James Thornton

Sources: New York Times 1, New York Times 2, MB
Photo: Red Orbit