Malaria remains one the world’s deadliest diseases, disproportionately affecting children in Africa. Global health organizations achieved a major breakthrough in the fight against this life-threatening infection in 2023 by rolling out the world’s first malaria vaccine: manufacturers have now slashed the price of this vaccine, along with a second approved vaccine, and it could be an important step in relieving the socioeconomic burden of the disease across the African continent.
In late 2025, Gavi, the Vaccine Alliance, and children’s agency UNICEF struck a pricing deal to cut the cost of the R21/Matrix-M vaccine to $2.99 USD from around $4. Analysts project that these reductions will unlock 30 million extra doses before 2030, protecting around 7 million children. This monumental pricing deal follows on from another cost reduction that Bharat Biotech and GSK announced in June of 2025, stating that they will progressively reduce the price of the RTS,S malaria vaccine by half, falling to less than $5 USD per dose.
A Crucial Vaccination Effort
Researchers initially struggled to develop an effective malaria vaccine: vaccines train the immune system to recognize proteins on the surfaces of infectious agents (e.g., bacteria, viruses). The infectious agent associated with malaria is Plasmodium falciparum, a parasite that can evade the immune system and change its surface proteins throughout its life cycle, thus finding a suitable vaccine to target the parasite became complicated.
When researchers achieved clinical breakthroughs in 2004 and refined a vaccine formula, it was time to move to human trials. The newly-named ‘RTS,S/AS01’ vaccine was administered to groups of young children across sub-Saharan Africa in the first rounds of human testing.
Trials ran from 2004 until 2015 and concluded that three doses of RTS,S was enough to reduce clinical malaria cases in children by up to 39%. In January 2024, a mass roll-out of the RTS,S vaccine began in Cameroon and authorities soon followed it with the distribution of the more cost-effective vaccine, R21/Matrix-M. Now, RTS,S and R21 vaccinations form part of routine childhood immunizations in more than 20 African countries, acting as a crucial tool for protecting children against deadly infections.
The Importance of Equitable Pricing in Immunization
Many factors influence the pricing of a vaccine introduced into the market, including patent protection, production cost and volume of contract. Notably, there is a positive correlation between a country’s Gross National Income (GNI) and the price point at which suppliers sell a dosage within the country- this is known as tiered pricing.
Rather than selling a vaccine at a flat rate, pharmaceutical companies use tiered pricing to charge high-income countries a higher price per dosage to balance affordability in lower-income markets, cover research and development (R&D) costs and generate profit. This improves the accessibility of vaccines regardless of geographical location and socioeconomic status.
However, malaria is a disease that primarily affects the Global South, therefore the market for the RTS,S and R21 vaccines for high-income countries in the Global North was almost non-existent. The typical vaccine development model and tiered pricing system could not be implemented, and external organizations, including the World Health Organization (WHO) and The Bill and Melinda Gates Foundation, filled the funding gaps.
The introduction of the second-ever malaria vaccine, R21, improved vaccine equity through accessibility: the formula has a lower concentration of antigens (the active ingredient in vaccines) whilst maintaining its efficacy, which drastically cuts manufacturing costs. Doses of R21 are better adapted to the African climate because of less strict requirements in cold chain storage and transport, reducing accidental wastage and ensuring more children receive protective immunization.
The Socioeconomic Impact of Immunity
The relationship between malaria and socioeconomic status can be considered bi-directional: malaria infection and recovery minimizes a person’s ability to work, attend school or perform caregiving duties, increasing the risk of experiencing poverty. Conversely, those living in poor conditions without access to adequate sanitation or health care face a higher risk of malaria infection and suffering more severe disease outcomes.
Therefore, immunity can break the cycle of poverty and malaria. As a whole, every $1 USD spent on vaccines saves between $16-44 USD on treatments and broader economic implications of disease. Driving down the price of each dose improves vaccine equity, ensuring that communities most affected by extreme poverty and seasonal malaria spikes will be among those protected.
However, immunization alone is not enough to decrease the malaria burden across the African continent. Research from Gavi, the Vaccine Alliance, demonstrates that the RTS,S vaccine is around 63% effective as a prevention tool, but when used in combination with insecticide-treated bed nets, indoor residual spraying and seasonal malaria chemoprevention (SMC), efficacy rises to 93%. Studies have shown that the malaria vaccine is least effective in children who come from low socioeconomic status households, this is likely due to a lack of health care access which prevents children from completing all three immunizations along with preventative SMC treatments.
What Will the Future of Malaria Vaccination Look Like?
More and more African countries are adopting affordable malaria vaccine strategies, and keeping this momentum will be the key to imagining a malaria-free future. Community engagement has proven to be a highly successful strategy in effort to relieve concerns regarding the vaccine’s safety and cost. In the early stages of vaccine roll-out in Cameroon, parents initially responded to the scheme with hesitancy: community and religious leaders drove up vaccine demand by encouraging open discussions at community meetings and disseminating misinformation. Following the success of Cameroon’s vaccination campaign, global health partners have adopted this person-led strategy by connecting with community leaders and technical experts directly.
Gavi has predicted that immunizing around 50 million children against malaria before 2030 could save more than 170,000 lives. An increasing number of children will have the opportunity to complete their education uninterrupted by disease and parents will be relieved of the costly burdens of caregiving and clinical treatments. African governments and communities have responded to the agreement to slash malaria vaccine prices with great optimism and will be a huge step in protecting the most vulnerable populations from poverty.
– Charlotte Bunn
Charlotte is based in Bristol, UK and focuses on Good News and Global Health for The Borgen Project.
Photo: Flickr









