Information and stories about malaria.

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New Malaria Vaccine Could Be The Solution to Africa’s Malaria Crisis

New Malaria Vaccine
As the summer draws to a close, so does the peak season for malaria infections in the West African nation of Burkina Faso. The Malaria Consortium estimates that up to 60% of malaria cases in the country occur during the period between July and November. The World Health Organization (WHO) 2021 malaria report notes that around 3% of global malaria deaths in 2020 took place in Burkina Faso alone. A new malaria vaccine could be the first step in tackling a disease that has plagued the African continent for decades.

The burden of malaria weighs heavily on the country’s population, especially in the Nanoro area, where researchers chose to trial a new vaccine in 2020. The results proved promising, and now, two years on, outcomes are still promising. A 2022 Lancet Infectious Diseases article suggests that, in combination with a booster dose administered one year after the original three doses, the vaccine remained highly effective in fighting malaria in children.

Malaria in Africa

Burkina Faso is not the only African nation tormented by this disease. In fact, the WHO’s 2021 malaria report stated that 95% of malaria cases in 2020 occurred in Africa, with Nigeria, the Democratic Republic of Congo (DRC) and Uganda facing the worst impacts. This is primarily because the parasite that causes the most life-threatening form of malaria, plasmodium falciparum, is native to many African countries.

The effects of endemic malaria on a country can be both far-reaching and devastating. An Against Malaria Foundation report states that not only is malaria one of the leading causes of death among children due to their fragile immune systems but it also causes long-term health issues because the severity of the illness prevents children from participating in social and educational activities that promote healthy development. The report also highlights the strain placed on African health care infrastructure while trying to treat malaria, which accounts for between 20% and 50% of hospital admissions on the continent.

Health-related issues aside, the malaria crisis has contributed significantly to stagnating and even setting back economic development in Africa for years. The WHO estimates that the growth in GDP per year of countries with high numbers of malaria cases stood at only around 0.4% over the period between 1965 and 1990 — 1.9% lower than other countries where malaria is not such a concern.

The New Vaccine

Scientists have been working on a vaccine to combat malaria for years, but to say this endeavor is an uphill battle is an understatement. The parasite exists in three stages once it is inside the human body, making it difficult to target; a vaccine may work against the parasite at one stage but not the next. The best candidate up until recently was RTS,S, but the efficacy of this vaccine wanes significantly after the first year.

While it is an acceptable candidate, for now, research into other options is necessary and ongoing. The R21 vaccine produced by the University of Oxford is the most promising yet. The WHO has set a target of 75% efficacy for a prospective malaria vaccine — initial results, published in the Lancet in 2021, found that the R21 vaccine’s efficacy was between 74% and 77% after six months, meeting the WHO goal.

Coupled with the three initial doses, a booster after one year proved to restore the efficacy of the vaccine to its original levels. On September 7, 2022, a follow-up article revealed that the R21 vaccine remained safe and effective one year after the booster dose, making this the most effective malaria vaccine yet.

Not only is R21 highly effective but it also appears to cause no side effects more serious than a fever. It is also set to be cheaper than its predecessor, RTS,S — Oxford vaccine expert Adrian Hill, speaking to Chemical Engineering News, suggested that R21 may be sold for less than $5 per dose.

Looking Ahead

The R21 vaccine could have a bright future, but it requires further testing, and that can only happen with funding. The WHO has not yet approved it for wider use, but researchers are hopeful that with further larger-scale trials, the vaccine could receive approval as early as next year.

Malaria drains government resources, strains health care infrastructure and lowers labor productivity, according to the Giving What We Can Project. It also kills hundreds of thousands of people every year. Investing in solutions, especially in terms of research into potential vaccines, could be the remedy to the ongoing malaria crisis that has plagued Africa for decades.

– Abbi Powell
Photo: Flickr

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Malaria No More UK’s Efforts to End Malaria

Malaria No More
Malaria No More (MNMUK) is a global charity aiming to end malaria – a disease that roughly half of the world’s population is at risk of contracting. The groups most susceptible to getting this disease are children under five and expectant mothers. Poorer communities also find themselves being hit harder by the disease, which negatively impacts children’s school attendance and adults attending work.

MNMUK believes that by working to increase government spending on ways to speed up the delivery of malaria prevention and treatment tools and simultaneously conveying their message to a broad population, the incidence of the disease will reduce. MNMUK’s hope is that mortality and incidence rates will decrease by 90% by 2030; in its eyes, this is the first step forward in eradicating the disease in the next several decades.

MNMUK Progress to End Malaria

One key MNMUK project is its global Zero Malaria campaign. The effects of the Zero Malaria campaign speak for themselves: 23 countries have launched the campaign so far and many more are on the cusp of joining. Politically, the charity was able to organize official parliamentary coalitions across Uganda and Tanzania and religious leaders have partaken in a march through Lusaka in Zambia to promote the Zero Malaria campaign.

MNMUK has also been able to support the African Union Commission in creating the Conversation Guide for Youth in Africa to encourage more young people to participate in the malaria response. The guide is helping young people engage in malaria policy dialogue and advocacy.

David Beckham and MNMUK

MNMUK decided to enlist one of the most famous faces worldwide to champion its cause to end malaria– David Beckham. Working with cutting-edge video technology, the charity had survivors of the disease speak through David Beckham’s face in nine different languages. Because of this, the campaign made the information accessible to more people. In this way, the David Beckham video enabled some of the most at-risk individuals to project their voices into society. Moreover, the video reached hundreds of millions of people and scooped up a CogX award for Outstanding Achievement in Social Good Use of AI (a concept in videography).

Accompanying the film was a behind-the-scenes montage featuring experts on malaria who are playing a crucial role in working to end malaria. Beckham has worked with MNMUK since 2009 and says the struggle against malaria is something that means a lot to him because the disease is especially fatal to children. Beckham has also commented on his enjoyment of meeting and working with the inspirational people involved in the charity.

– Claire Dickson
Photo: Flickr

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Hope for Malaria Eradication in the Caribbean

Malaria Eradication in the Caribbean
Malaria in today’s world is largely absent from the Caribbean due to the success of past eradication efforts. Despite this, total eradication in the Caribbean is not complete. The island of Hispaniola, which Haiti and the Dominican Republic shares, continues to combat the disease. In the 21st century, efforts focusing on the island have given hope that effective and complete elimination of the disease may be within reach. With the help of international allies, complete malaria eradication in the Caribbean is possible.

Understanding Malaria and Its Dangers

Malaria is a dangerous parasitic infection that humans can catch through female mosquito bites. Symptoms can manifest in various ways, such as fevers and muscle aches. Contracting the disease requires urgent medical care due to the severity of the illness. Symptoms can become extremely painful as they progress and, without treatment, malaria can result in death. While treatment can be effective, no vaccine currently exists against infection. This makes malaria an urgent issue that requires global action.

The dangers of malaria compound its impact on human health. The social and economic effects of malaria can be a major hindrance to a nation’s development. Pregnant women are one of the most vulnerable groups that malaria can affect. This threatens female attendance within education and hinders their participation in the general economy, thus widening the gender equality gap within affected nations such as Haiti or the Dominican Republic. The end result is that women are moving further into poverty.

A History of Malaria in the Caribbean

Malaria has existed across the globe for centuries with it being most prevalent in tropical regions. The Caribbean is no exception to this, however, there is some speculation regarding malaria’s introduction to the region. Theories have determined that malaria arrived in the Caribbean through European exploration of the Americas and the transatlantic slave trade. Epidemics continued to plague the entire region throughout the first half of the 20th century before widespread eradication efforts took hold.

Today, the World Health Organization’s Global Malaria Programme has placed a majority of the Caribbean nations on its certified list of malaria-free countries and territories. Programs such as this have supported malaria eradication in the Caribbean, while investments into health care systems have also helped the region get to where it is at now. These programs are typically a mixture of mass treatment as well as a targeted treatment for the most at-risk groups. As a result, Haiti and the Dominican Republic remain the last two countries within the Caribbean awaiting malaria eradication.

The Last Strong Hold

In 2004, the Dominican Republic was experiencing a rise in malaria cases. This came decades after most of the Caribbean had eliminated it. Reported infections rose by 31% that year alone. Due to the country being a major tourist destination, malaria affected many international visitors. At least 14 international tourists from Western Europe and North America contracted malaria during the spike. Although the risk to tourists remained low and still is to this day, the presence of the disease acts as a deterrent for potential visitors. The Dominican Republic relies heavily on tourist revenue, as do many of its island neighbors. This means that any threat to the industry could result in further impoverishment for the nation’s citizens.

Malaria has an even stronger albeit diminishing hold on neighboring Haiti. Haiti came close to eradicating malaria in 1968 through the Global Eradication Program. As a result, malaria’s presence within Haiti dropped to less than 1%. However, unfortunately, Haiti did not sustain its efforts to eliminate malaria due to a lack of funding and political instability. Haiti saw a rise in malaria cases in the 70s and the turmoil that Haiti’s 2010 earthquake caused further stifled efforts to combat the disease. The most recent statistics for 2020 showed a total of 22,987 cases in Haiti. Limited funds and natural disasters, among other political disturbances, have prevented malaria from being eliminated from the island of Hispaniola.

Solutions

Haiti’s National Malaria Control Program (NMCP), along with support from the U.S.-based CDC, has helped implement widespread testing as well as initiatives to control mosquito populations. These efforts have seen malaria cases in Haiti reduce by 50% since 2009. In 2015, the CDC worked with the Haitian government and researchers to collect blood samples and carry out surveys to identify activities that may be putting individuals at risk of catching malaria. The surveys encompassed approximately 20% of the population in Haiti’s Verrettes and La Chapelle communes. These efforts also extend across the island into the Dominican Republic.

The Pan American Health Organization (PAHO) also began operations in Haiti in response to the 2010 earthquake. Rapid diagnostic testing has now become the main method of tracking the spread of malaria across Haiti. Malaria elimination in the Caribbean is now in sight due to international efforts and interventions. With continued help, total malaria eradication will be a reality.

– Bryce Mathurin Lindsay
Photo: Flickr

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Ending Malaria and NTDs by 2030

End Malaria and Neglected Tropical Diseases
According to the World Health Organization (WHO) in 2020, there were approximately 241 million malaria cases globally. The African region accounted for 95% of the cases and 96% of the deaths. However, governments and other organizations, and companies have recently pledged to end malaria and neglected tropical diseases (NTDs) by 2030.

Historic Kigali Summit

On June 23, global leaders led by Rwanda President Paul Kagame convened at the Kigali Summit on malaria and neglected tropical diseases. This historic summit was the first to discuss these diseases in Africa. Members of the summit convened to discuss and introduce solutions and strategies to end malaria and neglected tropical diseases by 2030. The summit caused governments, companies, organizations, philanthropists and others in the private sector to commit more than $4 billion. Countries that these diseases affected donated more than $2.2 billion. Supporters similar to the Bill and Melinda Gates Foundation and Pfizer pledged a combined donation of more than one billion dollars to the cause. Additionally, pharmaceutical companies donated 18 billion medicine tablets to prevent and treat neglected tropical diseases.

The attendees highlighted specific goals to achieve to follow WHO’s global malaria strategy for 2016 to 2030. Some of the goals to reach completion by 2030 include:

  • Decreasing the number of new malaria cases by at least 90%
  • Decreasing malaria death rates by at least 90%
  • Ensuring at least 35 countries abolish malaria
  • Decreasing the number of people needing treatment for neglected tropical diseases by 90%
  • Eliminating dracunculiasis and yaws, two neglected tropical diseases.

Past Progress in Ending Malaria and NTDs

In the past, governments and other organizations have been working hard to end malaria and neglected tropical diseases. With the increase in government funding and access to treatment, malaria and neglected tropical diseases cases have decreased.

Here are a few achievements:

  • The number of malaria cases and deaths has significantly reduced since 2000. From 2000 to 2020, about 10.6 million malaria deaths and 1.7 billion malaria cases did not occur.
  • The WHO director-general labeled nine countries as free from malaria since 2015.
  • Forty-six countries have removed one NTD.
  • One billion people have received treatment for an NTD between 2015 and 2019.

Impact of Kigali Summit

While malaria and NTD cases have decreased since 2020, there is still a long way to go. The 2022 Global Malaria Action Plan by the Roll Back Malaria Partnership, a group of more than 500 organizations dedicated to ending malaria, emphasizes that 3.3 billion people in 109 countries are at risk of malaria. Each year, 185,000 people die because of an NTD. However, the Kigali Summit provides greater opportunities for treatment and preventative measures to fight these two deadly diseases for people worldwide, impacting billions of people.

The summit also demonstrates the cooperation of countries, organizations, and others and their dedication toward one goal. Because of the African leaders’ persistence through the COVID-19 crisis, they were able to secure high-level commitments of billions of dollars. The world is one step closer to the goal to end malaria and neglected tropical diseases by 2030.

Looking Ahead

Malaria and NTDs have affected billions of people across many countries worldwide. The dedication from governments, organizations and members of the private sector indicates a different future, one free of these deadly diseases. At the Kigali Summit, WHO Director-General Dr. Tedros Adhanom Ghebreyesus stated that “…we have the tools and the strategy to prevent that – and, with new tools, to start to dream of a malaria-free-world.”

– Janae O’Connell
Photo: Wikipedia Commons

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Malawi Uses Drones to Tackle Malaria

Drones to Tackle Malaria
Although it is a country of progress, Malawi faces social issues and is currently dealing with the impact of disease and finding solutions. The use of a technology method, specifically drones to tackle malaria, is helping to identify and eliminate mosquito breeding grounds and it could be the breaking point of innovation used to eradicate malaria throughout the nation.

Impact of Malaria on Malawi’s Health Care

In Malawi, malaria is the leading cause of death in young children. Each year, there are about 5 million cases of malaria. Experts believe that Malaria is responsible for 34% of all outpatient visits and 40% of all hospital admissions among children under the age of 5. Although Malawi strives to improve economically it still remains one of the world’s poorest nations.

More than 70% of the population lives in poverty, with $1.90 per day. According to the World Bank, the COVID-19 epidemic has had a significant impact on the economy of Malawi. This is because COVID-19 has had a negative monetary impact on economic growth and health care. Prior to COVID-19, telemedicine innovations were expanding due to their promise to provide accessible health care to remote populations that lack access to local resources or expertise.

Experts say that the overburdened health care system leads to increased cases of individuals dying from illnesses like malaria before receiving treatment and COVID-19 has slowed down health services. Therefore, lowering the possibility of transmission of malaria could be an essential part of the nation’s malaria control effort.

The Implementation

Malawi is using drones to tackle malaria in order to keep an eye on mosquito breeding sites in Malawi’s central district known as Kasungu. This is the way to assist scientists in mapping the locations of mosquito infestations in water bodies, according to the World Economic Forum. Along with the African Drone Academy and the Malawi-Liverpool-Wellcome Trust (MLW), researchers set out to track mosquito habitats in Kasungu. Kasungu is abundant in dams and reservoirs, which sustain insect breeding sites during the dry season, The Telegraph reported.

Researchers used drones to map prospective larval homes in an area of 10 kilometers squared by taking in-depth pictures of the area from a height of about 120 meters. With the help of a GPS, the researchers then sampled larvae in order to find out which areas were more prone to mosquito breeding. Following that, they monitored the possibility of exposure within the home, enabling extremely focused malaria disruption activities.

The Aftermath

It is evident that Malawi strives to curb the impact that malaria has on its people. A campaign has started in order to stop malaria by the year 2030 and such efforts have the potential to be achieved. The use of technology to curb issues within a modern world is showing to be progressive. In fact, according to The Telegraph, researchers claim that the investigation of using drones to tackle malaria has improved understanding of how minor dams and reservoirs impact mosquito populations.

The project’s success has encouraged the researchers to modify the technology to track the effects of plastic trash on the ecosystem and human health as well. Malawi’s continued progress and innovation could help the poor fight against malaria, leaving less of a burden on them for health care.

– Frema Mensah
Photo: Unsplash

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3 Ways to Combat Malaria in Vietnam

Malaria in Vietnam
According to the World Health Organization (WHO), the Southeast Asian country of Vietnam has made significant strides in reducing malaria cases. In 2008, Vietnam recorded 11,355 malaria cases. In 2017, cases dropped to 4,548, a 60% decrease. Between 2008 and 2017, malaria-induced deaths decreased by 76%. With the appropriate measures in place, malaria in Vietnam can soon become a disease of the past.

What is Malaria?

Malaria is a severe illness that transmits from mosquito bites of mosquitoes infected with the malaria parasite. Symptoms include fever, body aches, chills, nausea and vomiting. If untreated, malaria can be fatal. Vietnam is taking three crucial actions to combat malaria.

3 Actions to Combat Malaria in Vietnam

  1. Insecticide-Treated Mosquito Nets. Mosquitoes thrive in humidity and warm weather. In Vietnam, where tropical climate zones exist, it is essential to take deliberate actions to reduce the number of mosquitoes and mosquito bites in order to contain the spread of malaria. One can place Insecticide-treated mosquito nets (ITNs) over people’s beds while they sleep to shield them from insects. Insecticides that are safe for humans but toxic to mosquitoes and other insects coat the nets. These nets also repel mosquitoes, making mosquitoes less likely to get inside the home in the first place. The more households that own ITNs and use them correctly, the more likely that specific area will reduce the number of mosquitoes in the area, which would decrease malaria in Vietnam significantly. According to the Centers for Disease Control and Prevention (CDC), more than 50% of community members must use ITNs to experience an apparent drop in the mosquito population. A study that the World Bank conducted found that the use of ITNs for children younger than 5 years old in Vietnam stood at 9.4% in 2011. This is an increase from the percentage in 2006, which stood at 5%. If the use of ITNs continues in Vietnam, the prevalence of malaria cases will sink lower and lower.
  2. Artemisinin-Based Combination Therapy (ACT). ACT is an effective form of treatment used in malaria patients. It has contributed significantly not only to decreasing malaria in Vietnam but globally. Health care practitioners administer artemisinin with a partner drug and the two drugs work in conjunction with one another. While artemisinin “quickly and drastically reduces the majority of malaria parasites,” the partner drug tackles any remaining parasites. Between 1991 and 2014, Vietnam experienced a sharp decline in malaria cases attributed to the use of ACT. During this period, ACT treatment use rose by 10% and Vietnam noted a 32.8% decrease in malaria cases. As of 2003, ACT is free for all ages in the public sector, making treatment widely available to many Vietnamese citizens.
  3. NIMPE. The National Institute of Malariology, Parasitology and Entomology (NIMPE) is working to reduce malaria in Vietnam. The organization is based in Hanoi, Vietnam. Supervision teams travel to remote areas of the country where malaria is most prominent. In forested areas, people are more at risk of contracting malaria. In the early 2010s, about 50% of forest dwellers contracted malaria. Researchers at the NIMPE study microscopic analysis for the detection of malaria in certain areas. This is a crucial step in reducing cases. Sometimes, rapid diagnostic tests that citizens receive fail to pick up traces of malaria, even if the person has been infected with the sickness. Microscopic analyses provide a clearer picture of how many malaria cases are actively present. According to a senior technician from the Epidemiology Department of the NIMPE, Vu Thi Anh Tuyet, communication and awareness of malaria in Vietnamese communities is incredibly effective in fighting malaria. From 2018 to 2021, cases of malaria in Vietnam decreased by a staggering 90%.

Looking Ahead

Efforts continue with the aim to combat malaria in Vietnam. The country has made remarkable progress in reducing cases and deaths over the years. By recognizing and treating the disease, fewer infections will occur in the first place and Vietnam will have more productive citizens in good health to contribute to the economy.

– Megan Quinn
Photo: Flickr

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A Closer Look at Malaria in Nigeria

Malaria in NigeriaNigeria has the largest population in Africa with more than 200 million people. About 40% of Nigerians survive on less than $2 per day. The poverty rate in the country has led to an increase in unhygienic living conditions. Poor standards of living contribute to outbreaks of diseases. Malaria in Nigeria is endemic and stands as a life-threatening condition. Bites from an infected mosquito transmit malaria to a living host. Malaria is one of the leading disease burdens with high fatality rates in the country. Globally, reports of 627,000 malaria-related deaths occurred out of 241 million malaria cases in 2020. Pregnant women and children who are younger than 5 risk contracting the disease. Several factors contribute to the prevalence of malaria in Nigeria.

Weather Conditions

Nigeria experiences a tropical climate with rainy and dry weather conditions. In fact, “reports estimate that change in weather was responsible for 6% of malaria cases in some low and middle-income countries in the year 2000.” Weather influences the reproductive rate and life span of insect vectors that transmit diseases. There is an established association between weather and the incidence of malaria in Nigeria. The country experiences high levels of rainfall between June and September each year and there is a reported increase in malaria transmission during these humid months. Malaria is especially prevalent in the rural northern region of the country.

Overcrowded Living Conditions

Housing deficits in Nigeria lead to overcrowded living conditions. Nigeria noted 22 million housing shortages in 2018. The vector that transmits malaria spreads from an infected host through a mosquito bite. Overcrowded spaces serve as a conduit for disease outbreaks and can increase the risk of malaria because higher concentrations of carbon dioxide and other chemicals in crowded houses attract mosquitoes. In addition, reports suggest that poorly ventilated dwellings allow mosquitoes to enter more easily than well-constructed housing with screened windows, thus increasing disease transmission.

Poor Sanitary Conditions

Unhygienic living conditions serve as breeding sites for malaria-carrying mosquitoes. About 60 million Nigerians in 2021 lacked access to clean water and safe sanitary facilities. Lack of access to basic amenities hinders compliance to public health measures of proper handwashing and waste disposal. Poor sanitary conditions continue to hinder efforts in eliminating the disease across Nigeria.

Access to Quality Health Care

Malaria is a mosquito-borne disease that continues to stand as a significant public health crisis in Nigeria. It accounts for 30% of infant mortality and 11% of mortality cases, respectively. Nigeria shouldered 31.9% of global malaria deaths in 2020, ranking as the most malaria burdened nation in Africa. Prevention is key in controlling and eliminating malaria. However, about 83 million Nigerians lack access to health care services, resulting in high morbidity rates for those who have poorer health outcomes. 

Malaria Treatment

Concerted efforts from stakeholders to eradicate malaria in Nigeria have faced daunting challenges due partly to insurgent attacks on health workers. However, Nigeria is making progress in preventing new infections with the use of insecticide-treated mosquito nets and residual indoor spraying with special consideration for vulnerable groups such as pregnant women and children.

A collaboration between global partners and the Nigerian government in mitigating the effects of malaria accounts for the nation’s malaria progress. Initiatives from the Global Fund, Malaria Consortium, USAID, GAVI and Roll-Back Malaria have been successful in improving global health outcomes by reducing malaria deaths by 60% and saving 7.6 million lives. An estimated 100 million insecticide-treated mosquito nets have undergone distribution between 2017 and 2020 to control malaria in Nigeria. Impressively, malaria prevalence declined to 23% in 2018 from 42% in 2010.

In 2021, the World Health Organization (WHO) approved a vaccine as part of an effort toward eradicating malaria. Mosquirix vaccines are useful as part of malaria prevention strategies but funding from the global health community is necessary for a broader rollout. Access to Mosquirix vaccines will be effective in the fight against the spread of malaria in Nigeria and globally.

The Nigerian government launched the Malaria Eradication Fund to strengthen the country’s public health system in response to the challenge of the disease in 2021. Expectations determine that these resources will aid efforts geared toward the elimination of the disease in the country so that Nigeria can be certified malaria-free by the WHO in 2030.

– Sylvia Eimieho
Photo: Flickr

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Global Developments in the Fight Against Malaria

Fight Against Malaria
According to the World Health Organization (WHO) in 2019, malaria infections stood at almost 230 million globally. Of these malaria incidents, 409,000 cases led to fatalities. These are the striking and often overlooked numbers encasing the global fight against malaria. Malaria, a parasitic infection that mosquito varieties ruthlessly spread, is an ancient disease plaguing regions across the globe, particularly within the warmer climates of the tropical and subtropical areas of the world.

The cyclical nature of the disease from uninfected mosquitoes to infected hosts then infected mosquitoes to uninfected hosts, is in part the reason this disease is difficult to counteract outside of preventive measures, such as traditional nets, drugs and various forms of insecticides. However, these methods have limitations. The insidious nature of repeat infections adds insult to injury, with reports indicating up to six malaria infections annually among some children. Now, the dawn of a malaria vaccine hopes to make strides in the fight against malaria.

The Dawn of a Malaria Vaccine

The daunting reality and statistics on malaria illustrate only one side of the story on emerging aid over the last three decades. After years of research and trials by the manufacturer, on October 6, 2021, WHO officially authorized the widespread use of a malaria vaccine that GlaxoSmithKline created called Mosquirix. This is not only a win in the fight against malaria. Mosquirix is “also the first vaccine ever recommended for use by WHO to combat a parasitic disease in humans.”

Dr. Pedro Alonso, director of WHO’s global malaria program, says in a press release that “[i]t’s a huge jump from the science perspective to have a first-generation vaccine against a human parasite.” The vaccine, which targets children, has the potential to prevent “23,000 deaths in children younger than 5 each year.” As it stands, the vaccine manufacturer has “committed to producing 15 million doses of Mosquirix annually” until 2028.

Development in Tandem With the Global Health Order

This trend toward vaccination campaigns, development and authorization does not of course appear in a vacuum. After decades of stalling efforts on malaria prevention, a new global health order has ushered in a recent admiration for the efficacy of vaccine funding, research and implementation on the back of the global struggle against COVID-19. Organizations championing the global vaccine battle against COVID-19, such as GAVI, the Vaccine Alliance, “likely play a crucial role in negotiating the financing, procurement and delivery of” the Mosquirix vaccine.

Other major players in the fight against COVID-19 are also entering the ring. BioNTech recently launched a malaria project in July 2021. Its intentions are the use of mRNA technology, which has proven highly effective in COVID-19 vaccines, in the fight against the malaria parasite. Clinical trials of the world’s “first mRNA-based vaccine for malaria prevention” will begin at the close of 2022. These new multilateral and multi-agency relationships in health care, which the pandemic brought about, could be the stepping stones for future breakthroughs in global health.

Looking Ahead

Spurred on by new movements in global health, the malaria vaccine will make strides within infant and youth populations across at-risk regions like Africa and beyond. Mosquirix pilot programs in Kenya, Malawi and Ghana “found that the vaccine is safe. There is community demand for it and it is a cost-effective prevention method.” While perhaps not intrinsically linked to the new global health order, the world is making strides in combating an ancient and sometimes overlooked disease through emerging technologies, monetary funding and intellectual endorsements. It is safe to say that the new malaria vaccine could set new precedents as to the way the world cooperates on matters of global health security so that the international community can develop long-lasting strategies to keep at-risk regions safe, productive and healthy.

– Aidan Swayne
Photo: Flickr

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3 Diseases in Nigeria

Diseases in Nigeria
Nigeria ranked 142 out of 195 countries in a 2018 global health access study. However, although Nigeria has a challenging health care system, the country has improved the infrastructure that has helped it fight diseases such as polio, measles and Ebola. Nigeria now has centralized offices called Emergency Operation Centers (EOCs) that serve as a base for government health workers and aid agencies to coordinate immunization programs and collect data. While there is progress, many diseases still plague Nigeria.

Cholera

Cholera is a water-borne disease that results in a quick onset of diarrhea and other symptoms such as nausea, vomiting and weakness. It is one of the many diseases impacting Nigeria in 2021. If people with cholera do not receive treatment, the disease may kill them due to dehydration. A simple oral rehydration solution (ORS) can help most infected people replace electrolytes and fluids. The ORS is available as a powder to mix into hot or cold water. However, without rehydration treatment, about half of those infected with cholera will die, but if treated, the number of deaths decreases to less than 1%.

In August 2021, Nigeria began to see a rise in cholera cases, especially in the north, where the country’s health care systems are the least prepared. The state epidemiologist and deputy director of public health for Kano State, Dr. Bashir Lawan Muhammad, said the rise in cases is due to the rainy season. It is also because authorities have been dealing with Islamist militants in the north. In Nigeria, 22 of the 36 states have suspected cholera cases, which can kill in hours if untreated. According to the Nigeria Center for Disease Control, 186 people from Kano have died of cholera since March 2021, making up most of the country’s 653 deaths.

Malaria

Malaria is another one of the diseases affecting Nigeria. Through the bites of female Anopheles mosquitos, parasites cause malaria and transmit it to humans. Globally, there were 229 million malaria cases in 2019, with 409,000 deaths. Children under the age of 5 years old are the most susceptible group, and in 2019, they accounted for 274,000 or 67% of worldwide malaria deaths. That same year, 94% of malaria cases and deaths occurred in the WHO African Region. Although the disease is preventable and curable, the most prevalent malaria-carrying parasite in Africa, P. Falciparum, can lead to severe illness and death within 24 hours.

The President’s Malaria Initiative (PMI), which USAID and the CDC lead, works with other organizations to help more than 41 million Nigerians. Despite the difficulties that COVID-19 presented in 2020, the PMI was able to assist Nigeria to distribute 14.7 million treatment doses for malaria, 8.2 million of which went to pregnant women and children. Besides that, the “PMI also distributed 7.1 million insecticide-treated mosquito nets (ITNs), provided 7.2 million rapid test kits, and trained 9,300 health workers to diagnose and treat patients” of malaria. Before the PMI, only 23% of Nigerian households had bed nets, but since 2010, that number has risen to 43%. The PMI also aims to improve health systems and the skill of health workers to administer malaria-related services.

HIV

HIV (human immunodeficiency virus) attacks the immune system, leading to AIDS (acquired immunodeficiency syndrome). One can control the virus with proper medical care, but there is no cure. The disease is prevalent in Africa because it originated in chimpanzees in Central Africa. The virus likely spread to humans when the animals’ infected blood came into contact with hunters. Over the years, HIV spread across Africa and other parts of the world, becoming one of the diseases impacting Nigeria today.

The CDC works with the Federal Ministry of Health (FMOH) and other organizations to create and sustain HIV response programs in Nigeria. The CDC’s “data-driven approach” and prevention strategies and treatment strengthen the collaborative system in Nigeria. These include HIV treatment, HIV testing, counseling, services to help prevent mother-to-child transmissions and integrated tuberculosis (TB) and HIV services. TB is the leading cause of death among people living with HIV.

From October 2019 to September 2020, nearly 200,000 Nigerians tested positive for HIV and began treatment. During the same period, over 1 million HIV-positive people tested for TB. More than 5,000 of those individuals tested positive and began treatment for TB. By the end of September 2020, nearly 25,000 orphans and other vulnerable children received HIV/TB services through the CDC. Not only that, but all facilities in Nigeria that the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) supports now use TB BASICS, which is a program that “prevents healthcare-associated TB infection.”

In 2021, Nigeria will face many diseases. On the other hand, great strides are occurring to educate the Nigerian population on diseases like HIV, malaria and cholera. Despite efforts, there is still much more necessary work to reduce illness in Nigeria.

– Trystin Baker
Photo: Flickr

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Vaccine Aids in the Fight Against Malaria in Malawi

Malaria in Malawi
Malaria in Malawi remains a top concern for public health and the safety of the country. On a global scale, Malawi accounts for 2% of all malaria cases, placing it in the leading “20 countries with the highest malaria prevalence and mortality rates.” In 2019, Malawi’s population totaled more than 19 million. That same year, health facilities in the country reported almost 5.2 million cases of malaria. The sheer amount of malaria cases in Malawi is alarming in comparison to the total population number.

Malaria-endemic Regions

Looking at malaria objectively helps explain its high prevalence throughout Africa. As the World Health Organization (WHO) reported in 2019, Africa accounted for 94% of the 229 million malaria cases and 409,000 deaths worldwide. WHO notes that children younger than 5 made up 67% of these deaths. The transmission of the deadly parasite allows it to thrive in many countries throughout Africa, specifically after the spike in annual rains in November. The malaria parasite thrives in very humid, often hot and wet conditions, making Malawi a prime location for the spread of the parasite. While the country has worked to control rates of malaria in Malawi by offering health services, the country still struggles to control the sheer amount of cases present.

The Beginning of the Malaria Vaccine Pilot Program

In 2019, Malawi welcomed the world’s first malaria vaccine pilot program. The vaccine, referred to as RTS,S, targeted children ages two and younger. GlaxoSmithKline is the producer of RTS,S, which underwent clinical trials after 30 years of refining. The vaccine trials found that RTS,S was able to prevent about four out of every 10 cases of malaria. The pilot project in Malawi aimed to gather observations and evidence of actual vaccine implementation to guide WHO in its policy recommendations for the use of RTS,S on a broader scale. The criteria observed included child mortality, vaccine follow-up and vaccine safety. Although the intention of the vaccine is not to replace other preventative measures, WHO hopes to add it to its bundle of malaria prevention recommendations.

The World Health Organization Approves the Vaccine

On October 6, 2021, WHO officially endorsed the use of the RTS,S vaccine worldwide, now called the Mosquirix malaria vaccine. This approval comes after two years of trials in three African countries (including Malawi) where more than 800,000 children received the vaccine. The vaccine can prevent severe and fatal cases of malaria at a rate of 30%. Since the pilot program implementation in 2019, WHO has been able to justify the ability of countries to roll out the vaccine safely. Although the vaccine itself is not 100% effective, it works as a preventative measure, reducing the likelihood of contracting a deadly case of malaria in Malawi. The rollout of this vaccine comes after decades of unsuccessful attempts to find a form of protection against malaria.

Economic Benefits of a Preventative Measure

Access to the Mosquirix vaccine will not only protect public health and safety but will also relieve the stress on Malawi’s economy. For years, programs focused on treating malaria in Malawi reactively. Given that treatment options are more widely available than prevention methods, health system responses have centered on reactivity rather than proactivity. As a result, the first response to malaria cases is often drugs. Drugs are both expensive and difficult to obtain. Furthermore, the malaria parasite adapts over time, becoming resistant to medications and decreasing the efficacy of drugs. Access to a proactive vaccine addresses the issue beforehand, saving costs in both healthcare visits and treatments in the long run.

Moving Forward

Malaria is a unique illness in that it involves a parasite that can strike an individual several times. In many parts of sub-Saharan Africa, this reality is concerning. On a yearly basis, children average a total of six malaria infections. The continued attacks on their immune systems leave them susceptible to other diseases. However, with the new vaccine comes new hope in the fight against malaria in Malawi. While the approval of the vaccine is only the first step in widespread change, the next few years present a strong opportunity for progress in some of the most vulnerable communities.

– Chloe D’Hers
Photo: Flickr