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The RTS,S Vaccine Protects Against Malaria

RTS,S VaccineA new vaccine known as the RTS,S vaccine is currently being piloted in the African nations of Ghana, Malawi and Kenya.  The RTS,S vaccine has been in development for over 32 years. It is the first malaria vaccine that has been shown to provide young children with partial protection from malaria.

What is Malaria?

Every single year, the malaria virus kills one million people around the world. It is estimated that 300-600 million people suffer from malaria every year. Additionally, 90 percent of malaria cases occur in Sub-Saharan Africa. The majority of malaria’s victims are children under the age of five.

According to UNICEF, Malaria kills one child every thirty seconds, which is about 3,000 children every single day. Malaria hinders children’s social development and schooling. Furthermore, malaria is a major cause of poverty. For example, the cost of malaria control and treatment actually slows economic development in Africa by 1.3 percent.

RTS,S Malaria Vaccine Pilots

In clinical trials, the RTS,S vaccine was found to prevent about 4 out of 10 malaria cases. Additionally, it proved to prevent 3 in 10 cases of severe, life-threatening malaria. The malaria vaccine has also been shown to reduce severe malaria anemia by 60 percent. Severe malaria anemia is the most prevalent reason that children die from malaria.

The organizations of Unitaid, Gavi, the Vaccine Alliance and the Global Fund to Fight Aids, Tuberculosis and Malaria funded and supported these pilots.

Impact

Currently, an estimated 360,000 children are expected to receive the RTS,S vaccine through immunization programs in certain areas of Malawi, Ghana and Kenya. However, the main weakness of the immunization programs is in how they store and transport the vaccines. The effectiveness of a vaccine is dependent on whether it is in a properly-functioning cold chain. This refers to a system of transporting and storing vaccines at the proper temperatures from when they are manufactured to when they are used.

To ensure that vaccines properly fulfill their duty of vaccinating children from malaria, there needs to be an increased focus on the protection and storage of these vaccines in their proper cold chains. It is vital to invest in proper storage equipment and maintenance of that storage equipment. This equipment will retain the vaccine’s efficacy. It is also crucial to invest in roads and infrastructure so the vaccines can be properly transported to those in need.

Innovation

A technological innovation that has changed and improved the transportation of malaria vaccines is the use of drones. The Rwandan tech firm Zipline has already launched drones that are used to transport medication, vaccines, blood and other essential health care items.

Starting out in Rwanda, the firm has also expanded its lifesaving services into Ghana. The drones fly at 100 kilometers and are able to make deliveries in 30 minutes that otherwise could take five hours by car. The drones also are able to fly through any type of terrain. Therefore, they can easily reach remote villages without requiring any sort of local infrastructure at the scene. ZipLine is able to make up to 500 delivers a day. Thanks to its services, ZipLine has provided 13 million people instant access to urgent, life-saving treatments.

The RTS,S vaccine is an effective vaccine that is vital in protecting young children from malaria. By drastically reducing cases of severe malaria anemia, the RTS,S vaccine is saving lives. To continue saving lives and to further build the efficacy of the vaccine, it is crucial to focus on investing in the proper infrastructure for storage and transportation of the vaccine.

– Nicholas Bykov
Photo: Flickr

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Testing of the First Malaria Vaccine Begins in Malawi

First Malaria Vaccine
Malaria is a parasitic virus transmitted through mosquito bites, and those infected with the disease often experience grave fevers, chills and flu-like symptoms. Although malaria can potentially end in death, physical precautions such as safety nets in malaria-dense environments and prompt treatment can usually prevent it. Unfortunately, because malaria largely affects poorer nations, it can be a great strain on national economies and impoverished populations. The World Health Organization is enlisting pilot testing for the first malaria vaccine.

The Problem

Malaria reportedly infects tens of millions, killing over 400,000 people worldwide every year and mostly children; Sub-Saharan African countries are the primary nations in which malaria thrives—the World Health Organization estimates that over 250,000 African children die every year from the virus.

The malaria-carrying parasite is able to evade victims’ immune systems by constantly changing its surface, which is why developing a vaccine against the virus has been so difficult. With today’s modern technology and scientific insight, that is beginning to change.

Testing the First Malaria Vaccine

In April of 2019, a large-scale pilot test of what many are dubbing the world’s first malaria vaccine to give partial protection to children began in Malawi. Scientists from the drug company GSK first created the RTS,S vaccine in 1987 and has been refining it ever since. Organizations like Path Malaria Vaccine Initiative have been instrumental in supporting this initiative.

The new RTS,S vaccine is attempting to teach the immune system how to attack the malaria parasite. A patient needs to receive the vaccine four times—once a month for three months, followed by a fourth and final dose 18 months later. In 2009, Kenya held smaller trials of the vaccine and concluded with a 40 percent protection rate of the five to-17 month-olds who received the vaccination. Since then, malaria rates have plateaued rather than decreased, which is another reason the new pilot test is so vital in the modern-day.

Now testing is taking place in Malawi, Kenya and Ghana with aims to immunize 120,000 children aged two-years-old and younger. These three countries are ideal for two reasons: one, these nations already have large anti-malaria programs in place; and two, in spite of this, they still have high numbers of malaria cases. As Dr. Matshidiso Moeti (World Health Organization Regional Director for Africa) stated, “Malaria is a constant threat to the African communities where this vaccine will be given” and explains that the vaccine is needed because “we know the power of vaccines to prevent killer diseases and [hope to] reach children, including those who may not have immediate access to the doctors, nurses and health facilities they need to save them when severe illness comes.”

Looking Towards the Future

The purpose of the pilot tests is to build up evidence that can be reliably considered while WHO policy is debating its recommendations on the broader use of the RTS,S vaccine. The experiment will examine the reductions (if any) in child deaths, vaccine uptake rates (including how many children receive all four vaccinations) and the overall safety of the vaccine in routine use.

If the testing goes well, not only will the World Health Organization aid the vaccine to its core package of recommended measures for malaria prevention and treatment, but hopefully, it will begin a chain reaction that again sparks a decrease in malaria cases around the world.

– Haley Hiday
Photo: Flickr